Lam D M, Su Y Y, Watt C B
Brain Res. 1986 Sep;396(3):249-57. doi: 10.1016/0165-0173(86)90014-7.
Although the co-localizations of neuroactive substances, such as transmitters and peptides, in identified neurons is now a common histochemical phenomenon, the physiological roles and functional significance of such co-existence are largely unknown. Using the vertebrate retina as a model for the central nervous system, we have examined the relationship between co-existence and co-function. We propose here that the co-localization of neuroactive substances in a synaptic terminal provides the structural configuration to ensure the co-release of two or more predetermined substances into the same synaptic cleft, resulting in the capability of the presynaptic neuron to stringently regulate its own activities and output.
尽管神经活性物质（如递质和肽类）在已鉴定神经元中的共定位现在是一种常见的组织化学现象，但这种共存的生理作用和功能意义在很大程度上尚不清楚。我们以脊椎动物视网膜作为中枢神经系统的模型，研究了共存与协同功能之间的关系。我们在此提出，神经活性物质在突触终末的共定位提供了一种结构配置，以确保两种或更多种预定物质共同释放到同一突触间隙中，从而使突触前神经元能够严格调节自身的活动和输出。
