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特征假说:神经活性物质的共定位作为用于回路分析的解剖学探针。

The signature hypothesis: co-localizations of neuroactive substances as anatomical probes for circuitry analyses.

作者信息

Lam D M, Li H B, Su Y Y, Watt C B

出版信息

Vision Res. 1985;25(10):1353-64. doi: 10.1016/0042-6989(85)90213-5.

DOI:10.1016/0042-6989(85)90213-5
PMID:2868566
Abstract

The recent discoveries that a neuron in the vertebrate retina may contain more than one neuroactive substance (transmitter or neuropeptide) raise the possibility that within each class of neurons, every morphologically and physiologically distinct cell type may be uniquely identified and categorized by the neuroactive substances that it contains. This article examines the evidence to-date for such a conjecture and discusses some of its potential applications and implications.

摘要

最近的发现表明,脊椎动物视网膜中的一个神经元可能含有不止一种神经活性物质(递质或神经肽),这就增加了一种可能性,即在每一类神经元中,每一种形态和生理上不同的细胞类型都可能通过其所含的神经活性物质被独特地识别和分类。本文研究了迄今为止支持这一推测的证据,并讨论了其一些潜在的应用和影响。

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The signature hypothesis: co-localizations of neuroactive substances as anatomical probes for circuitry analyses.特征假说:神经活性物质的共定位作为用于回路分析的解剖学探针。
Vision Res. 1985;25(10):1353-64. doi: 10.1016/0042-6989(85)90213-5.
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Quantitative studies of enkephalin's coexistence with gamma-aminobutyric acid, glycine and neurotensin in amacrine cells of the chicken retina.
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Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina.
质膜相关 syntaxin 1 至 4 的分布表明其在小鼠视网膜突触层具有不同的运输功能。
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Colocalization of (3H)-adenosine accumulation and GABA immunoreactivity in the chicken and rabbit retinas.鸡和兔视网膜中(3H)-腺苷积累与γ-氨基丁酸免疫反应性的共定位。
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Enkephalin in the goldfish retina.金鱼视网膜中的脑啡肽。
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Microtubule-associated protein 2 (MAP2)-immunoreactive neurons in the retina of Bufo marinus: colocalisation with tyrosine hydroxylase and serotonin in amacrine cells.海蟾蜍视网膜中微管相关蛋白2(MAP2)免疫反应性神经元:在无长突细胞中与酪氨酸羟化酶和5-羟色胺的共定位
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