Nanotechnology Research and Application Center, Sabanci University, Istanbul, Turkey.
Center of Excellence for Functional Surfaces and Interfaces for Nano Diagnostics (EFSUN), Sabanci University, Istanbul, Turkey.
Can J Gastroenterol Hepatol. 2018 Aug 29;2018:8543763. doi: 10.1155/2018/8543763. eCollection 2018.
The proportion of obese or diabetic population has been anticipated to increase in the upcoming decades, which rises the prevalence of nonalcoholic fatty liver disease (NAFLD) and its progression to nonalcoholic steatohepatitis (NASH). Recent evidence indicates that NASH is the main cause of chronic liver diseases and it is an important risk factor for development of hepatocellular carcinoma (HCC). Although the literature addressing NASH-HCC is growing rapidly, limited data is available about the etiology of NASH-related HCC. Experimental studies on the molecular mechanism of HCC development in NASH reveal that the carcinogenesis is relevant to complex changes in signaling pathways that mediate cell proliferation and energy metabolism. Genetic or epigenetic modifications and alterations in metabolic, immunologic, and endocrine pathways have been shown to be closely related to inflammation, liver injury, and fibrosis in NASH along with its subsequent progression to HCC. In this review, we provide an overview on the current knowledge of NASH-related HCC development and emphasize molecular signaling pathways regarding their mechanism of action in NASH-derived HCC.
预计未来几十年肥胖或糖尿病患者的比例将会增加，这将导致非酒精性脂肪性肝病（NAFLD）及其向非酒精性脂肪性肝炎（NASH）的进展。最近的证据表明，NASH 是慢性肝病的主要病因，也是肝细胞癌（HCC）发展的重要危险因素。尽管关于 NASH-HCC 的文献正在迅速增加，但关于 NASH 相关 HCC 的病因学的数据有限。关于 NASH 中 HCC 发展的分子机制的实验研究表明，癌变与介导细胞增殖和能量代谢的信号通路的复杂变化有关。遗传或表观遗传修饰以及代谢、免疫和内分泌途径的改变已被证明与 NASH 中的炎症、肝损伤和纤维化密切相关，并且随后进展为 HCC。在这篇综述中，我们概述了 NASH 相关 HCC 发展的最新知识，并强调了分子信号通路及其在 NASH 衍生 HCC 中的作用机制。
