Jiang Chun-Meng, Pu Chun-Wen, Hou Ya-Hui, Chen Zhe, Alanazy Mohammed, Hebbard Lionel
Chun-Meng Jiang, Ya-Hui Hou, Department of Digestive System, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China.
World J Gastroenterol. 2014 Nov 28;20(44):16464-73. doi: 10.3748/wjg.v20.i44.16464.
Hepatocellular carcinoma (HCC) is increasing in prevalence and is one of the most common cancers in the world. Chief amongst the risks of attaining HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The later has been shown to promote non alcoholic fatty liver disease, which can lead to the inflammatory form non alcoholic steatohepatitis (NASH). NASH is a complex metabolic disorder that can impact greatly on hepatic function. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give an overview of the recent novel mechanisms published that have been associated with NASH and subsequent HCC progression. We will focus our discussion on inflammation and gut derived inflammation and how they contribute to NASH driven HCC.
肝细胞癌（HCC）的患病率正在上升，是世界上最常见的癌症之一。罹患HCC的主要风险包括乙型和丙型肝炎感染、黄曲霉毒素B1摄入、酗酒和肥胖。后者已被证明会促进非酒精性脂肪性肝病，进而可能导致炎症性非酒精性脂肪性肝炎（NASH）。NASH是一种复杂的代谢紊乱疾病，会对肝功能产生重大影响。NASH促进HCC的机制才刚刚开始得到阐明。在这篇综述中，我们概述了最近发表的与NASH及随后的HCC进展相关的新机制。我们将重点讨论炎症和肠道源性炎症，以及它们如何导致NASH驱动的HCC。
