Department of Psychology and Human Development, Vanderbilt University, 230 Appleton Pl, Nashville, TN, 37203, USA.
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, T-1218 Medical Center North, 1161 21st Avenue South, Nashville, TN, 37232-2650, USA.
Curr Psychiatry Rep. 2018 Sep 18;20(11):102. doi: 10.1007/s11920-018-0961-4.
To evaluate the degree to which recent studies provide evidence that the effects of prenatal maternal stress (PNMS) on child health outcomes vary depending on the child's biological sex. In this review, we used a broad definition of stress, including negative life events, psychological stress, and established stress biomarkers. We identified 50 peer-reviewed articles (published January 2015-December 2017) meeting the inclusion criteria.
Most articles (k = 35) found evidence of either sex-specific associations (significant in one sex but not the other) or significant PNMSstress interactions for at least one child health outcome. Evidence for sex-dependent effects was strongest in the group of studies evaluating child neural/nervous system development and temperament as outcomes. There is sufficient evidence of sex-dependent associations to recommend that researchers always consider the potential role of child sex in PNMS programming studies and report descriptive statistics for study outcomes stratified by child biological sex.
评估近期研究在多大程度上提供了证据表明,产前母体应激(PNMS)对儿童健康结果的影响因儿童的生物性别而异。在本综述中,我们使用了广义的应激定义,包括负面生活事件、心理压力和既定的应激生物标志物。我们确定了 50 篇符合纳入标准的同行评审文章(发表于 2015 年 1 月至 2017 年 12 月)。
大多数文章(k=35)发现了至少一种儿童健康结果存在性别特异性关联(在一种性别中显著,但在另一种性别中不显著)或 PNMS 应激相互作用的证据。在评估儿童神经/神经系统发育和气质为结果的研究组中,证据表明存在性别依赖性影响。有足够的证据表明存在性别依赖性关联,建议研究人员始终考虑儿童性别在 PNMS 编程研究中的潜在作用,并按儿童生物性别对研究结果报告描述性统计数据。