Gholipoor Peyman, Saboory Ehsan, Ghazavi Ahad, Kiyani Arezoo, Roshan-Milani Shiva, Mohammadi Sedra, Javanmardi Elmira, Rasmi Yousef
Department of Neurosurgery, Urmia University of Medical Sciences, Urmia, Iran.
Neurophysiology Research Center, Urmia University of Medical sciences, Urmia, Iran.
Epilepsy Behav. 2017 Jul;72:22-27. doi: 10.1016/j.yebeh.2017.04.021. Epub 2017 May 29.
Neurological disorders can be exacerbated in an offspring that is exposed to stress prenatally. This study is aimed to investigate the severity of febrile seizures (FS) in the offspring under 2years old that were prenatally stressed. In this study, 158 children below 2years old with FS were selected. Information about convulsion including seizure lasting, recurrence of seizure, age of the first seizure and type of FS was gathered. Blood samples were obtained from the offspring to measure the cortisol blood levels. Questionnaire was filled in to evaluate the perceived stress and exposure or non-exposure to major stresses during pregnancy. Results of this study showed that both high Perceived Stress Scores (PSS) during pregnancy and exposure to major stresses during pregnancy significantly increased seizure duration and seizure intensity. Also, the appearance of complex FS was significantly higher in prenatally stressed children than the unexposed ones. Further, cortisol blood levels were significantly higher in prenatally stressed subjects. It can be concluded that both higher PSS and/or exposure to major stresses during pregnancy potentiate FS parameters and lead to long lasting increase in cortisol blood levels in the offspring.
神经系统疾病在产前遭受应激的后代中可能会加重。本研究旨在调查产前遭受应激的2岁以下后代热性惊厥（FS）的严重程度。在本研究中，选取了158名2岁以下患有FS的儿童。收集了包括惊厥持续时间、惊厥复发、首次惊厥年龄和FS类型等惊厥信息。从后代中采集血样以测量血液中的皮质醇水平。填写问卷以评估感知到的压力以及孕期是否经历或未经历重大压力。本研究结果表明，孕期高感知压力评分（PSS）以及孕期经历重大压力均显著增加惊厥持续时间和惊厥强度。此外，产前遭受应激的儿童出现复杂性FS的比例显著高于未遭受应激的儿童。此外，产前遭受应激的受试者血液中的皮质醇水平显著更高。可以得出结论，孕期较高的PSS和/或经历重大压力会增强FS参数，并导致后代血液中皮质醇水平长期升高。
