lncRNA PTENP1 多态性与中国人口腔鳞状细胞癌风险的关系。
Polymorphisms in lncRNA PTENP1 and the risk of oral squamous cell carcinoma in a Chinese population.
机构信息
Department of Stomatology, Central Hospital Affiliated to Qingdao University, Qingdao, China.
出版信息
Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5583-5587. doi: 10.26355/eurrev_201809_15822.
OBJECTIVE
PTENP1, a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. The relationship between PTENP1 and susceptibility tumors is reported, while, an association of PTENP1 with the risk of oral squamous cell carcinoma (OSCC) in Chinese population is lacked. This research is designed to investigate the association of PTENP1 with susceptibility of OSCC.
PATIENTS AND METHODS
In this research, TaqMan technology was used to test genotype in 342 OSCC patients and 711 healthy controls, so as to analyze the association between PTENP1 polymorphisms (rs7853346 rs865005 and rs10971638) and susceptibility of oral squamous cell carcinoma.
RESULTS
The results of this research showed that rs7853346 [Additive model: Adjusted odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.66-0.99] was related to the OSCC risk. It was not found that the other two sites were associated with the susceptibility of OSCC.
CONCLUSIONS
This research indicated that rs7853346 is statistically correlated with the OSCC risk.
目的
PTENP1 是一种长链非编码 RNA，先前已有报道称其与肿瘤发生和癌症进展有关。虽然已经报道了 PTENP1 与肿瘤易感性之间的关系，但在中国人群中，PTENP1 与口腔鳞状细胞癌（OSCC）风险的关联尚缺乏研究。本研究旨在探讨 PTENP1 与 OSCC 易感性的关系。
方法
本研究采用 TaqMan 技术对 342 例 OSCC 患者和 711 例健康对照者的基因型进行检测，分析 PTENP1 多态性（rs7853346、rs865005 和 rs10971638）与口腔鳞状细胞癌易感性的关系。
结果
本研究结果表明，rs7853346[加性模型：调整后的比值比（OR）=0.81，95%置信区间（CI）=0.66-0.99]与 OSCC 风险相关。其他两个位点与 OSCC 的易感性没有关联。
结论
本研究表明，rs7853346 与 OSCC 风险具有统计学相关性。
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