Department of Otorhinolaryngology, Weifang People's Hospital, Weifang, Shandong, China.
Eur Rev Med Pharmacol Sci. 2017 Oct;21(17):3770-3774.
H19, a maternally expressed imprinted gene transcribing a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. The relationship between H19 and susceptibility of multiple tumors is inconsistent, and currently there is a lack of association of H19 with the risk of oral squamous cell carcinoma (OSCC). The objective to design this research is to investigate and discuss the association of H19 with susceptibility to oral squamous cell carcinoma in Chinese population.
In this research, Illumina Infinium Human Exome BeadChip technology was used for genetic tests in 362 patients who were pathologically diagnosed with new-onset OSCC and 741 healthy controls with matching gender and age, so as to analyze the association of H19 gene polymorphism sites (rs2735971, rs217727, rs2839698 and rs3024270) with susceptibility of OSCC.
The results of this research showed that rs217727 [Additive model: adjusted odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.02-1.46; AA vs. GG: Adjusted OR = 1.20, 95% CI = 1.00-1.44] was related to the susceptibility of oral squamous cell carcinoma. It was not found in the results that the other three sites were associated with the susceptibility of oral squamous cell carcinoma.
It is indicated in this research that rs217727 is statistically correlated with the susceptibility of OSCC.
H19 是一种母系表达的印迹基因，转录出一种长非编码 RNA，先前已被报道参与肿瘤发生和癌症进展。H19 与多种肿瘤的易感性之间的关系不一致，目前尚无 H19 与口腔鳞状细胞癌（OSCC）风险相关的关联。本研究旨在探讨和讨论 H19 与中国人群口腔鳞状细胞癌易感性的关系。
本研究采用 Illumina Infinium Human Exome BeadChip 技术对 362 例经病理诊断为新发 OSCC 的患者和 741 例性别和年龄匹配的健康对照进行基因检测，以分析 H19 基因多态性位点（rs2735971、rs217727、rs2839698 和 rs3024270）与 OSCC 易感性的关系。
本研究结果表明，rs217727[加性模型：调整后的优势比（OR）=1.22，95%置信区间（CI）=1.02-1.46；AA 与 GG：调整后的 OR=1.20，95%CI=1.00-1.44]与口腔鳞状细胞癌的易感性有关。其他三个位点与口腔鳞状细胞癌的易感性无关。
本研究表明 rs217727 与 OSCC 的易感性具有统计学相关性。
