Department of Anorectal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Eur Rev Med Pharmacol Sci. 2018 Sep;22(17):5635-5639. doi: 10.26355/eurrev_201809_15829.
To investigate the correlations between 25-hydroxyvitamin D3 (25-OHD3) level in patients with ulcerative colitis (UC) and inflammation level, immunity, disease activity.
The serum level of 25-OHD3, inflammation status, immunity level and disease activity in patients (n=122) with UC in our hospital from 2015 to October 2017 were evaluated and analyzed.
The levels of inflammatory factors [C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] in low 25-OHD3 group were higher than those in non-low 25-OHD3 group (p<0.01 and p<0.05), and both expressions of CRP and TNF-α in patients presented linearly negative correlations with the level of 25-OHD3 (r²=0.8351, r²=0.7298). There were no significant differences in the levels of immunoglobulin G (IgG) and complement C3 in low 25-OHD3 group compared with those in non-low 25-OHD3 group (p>0.05). There was an overall decreasing trend of 25-OHD3 level as disease activity increased, and there were statistically significant differences in the levels of 25-OHD3 in each group in remission period and mild, moderate and severe activity periods. The disease activity score of patients showed a linearly negative correlation with the level of 25-OHD3 (r²=0.8465). The level of 25-OHD3 in the observation group (treated with mesalazine combined with vitamin D) was increased with the time of medication, and the level was higher than that in the control group (treated with mesalazine only). CRP, TNF-α, and disease activity score in the observation group were decreased with the time of medication, and the level was lower than that in the control group.
The level of 25-OHD3 in UC patients is linearly correlated with the level of inflammation and disease activity. At the same time, combined treatment with vitamin D improves the reducing level of inflammation and limits the disease activity. Therefore, 25-OHD3 can be used in the assessment of the level of inflammation and disease activity, and as a potential tool in the treatment.
研究溃疡性结肠炎（UC）患者 25-羟维生素 D3（25-OHD3）水平与炎症水平、免疫、疾病活动之间的相关性。
评估和分析我院 2015 年 10 月至 2017 年 10 月期间 122 例 UC 患者的血清 25-OHD3 水平、炎症状态、免疫水平和疾病活动。
低 25-OHD3 组的炎症因子 [C 反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）]水平高于非低 25-OHD3 组（p<0.01 和 p<0.05），且 CRP 和 TNF-α 的表达均与 25-OHD3 水平呈线性负相关（r²=0.8351，r²=0.7298）。低 25-OHD3 组与非低 25-OHD3 组的免疫球蛋白 G（IgG）和补体 C3 水平无显著差异（p>0.05）。随着疾病活动度的增加，25-OHD3 水平呈整体下降趋势，缓解期和轻度、中度、重度活动期各组 25-OHD3 水平差异均有统计学意义。患者的疾病活动评分与 25-OHD3 水平呈线性负相关（r²=0.8465）。观察组（用美沙拉嗪联合维生素 D 治疗）的 25-OHD3 水平随用药时间的延长而升高，且高于对照组（仅用美沙拉嗪治疗）。观察组的 CRP、TNF-α 和疾病活动评分随用药时间的延长而降低，且低于对照组。
UC 患者 25-OHD3 水平与炎症水平和疾病活动呈线性相关。同时，维生素 D 联合治疗可改善炎症的降低水平并限制疾病活动。因此，25-OHD3 可用于评估炎症和疾病活动水平，并作为潜在的治疗工具。
