Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Pure North S'Energy Foundation, Calgary, Canada.
J Cell Physiol. 2019 May;234(5):5372-5378. doi: 10.1002/jcp.27372. Epub 2018 Sep 19.
Pancreatic cancer has a high mortality rate due to the absence of early symptoms and subsequent late diagnosis; additionally, pancreatic cancer has a high resistance to radio- and chemotherapy. Multiple inflammatory pathways are involved in the pathophysiology of pancreatic cancer. Melatonin an indoleamine produced in the pineal gland mediated and receptor-independent action is the pancreas and other where has both receptors. Melatonin is a potent antioxidant and tissue protector against inflammation and oxidative stress. In vivo and in vitro studies have shown that melatonin supplementation is an appropriate therapeutic approach for pancreatic cancer. Melatonin may be an effective apoptosis inducer in cancer cells through regulation of a large number of molecular pathways including oxidative stress, heat shock proteins, and vascular endothelial growth factor. Limited clinical studies, however, have evaluated the role of melatonin in pancreatic cancer. This review summarizes what is known regarding the effects of melatonin on pancreatic cancer and the mechanisms involved.
由于缺乏早期症状和随后的晚期诊断，胰腺癌的死亡率很高；此外，胰腺癌对放射和化疗具有很高的抗性。多种炎症途径参与了胰腺癌的病理生理学过程。褪黑素是一种在松果腺中产生的吲哚胺，具有介导和受体非依赖性作用，在胰腺和其他组织中均有受体。褪黑素是一种强大的抗氧化剂和组织保护剂，可抵抗炎症和氧化应激。体内和体外研究表明，褪黑素补充是治疗胰腺癌的一种合适方法。褪黑素可能通过调节大量分子途径，包括氧化应激、热休克蛋白和血管内皮生长因子，成为癌细胞中有效的凋亡诱导剂。然而，有限的临床研究评估了褪黑素在胰腺癌中的作用。本文综述了褪黑素对胰腺癌的作用及其相关机制。
