褪黑素在肿瘤学中的多方面作用：深入了解其在癌症治疗中的潜在应用

Multifaceted roles of melatonin in oncology: an insight into its therapeutic potential in cancer management.

作者信息

Maghsoudi Hossein, Sheikhnia Farhad, Hajmalek Nooshin, Gholipour Fatemeh Dadash, Alipour Shahriar, Ghorbanpour Mansour, Farzanegan Sara, Mir Seyed Mostafa, Memar Mohammad Yousef

机构信息

Student Research Committee, Urmia University of Medical Sciences, Urmia, 57147-83734, Iran.

Department of Clinical Biochemistry and Applied Cell Sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, 57147-83734, Iran.

出版信息

Inflammopharmacology. 2025 Apr 22. doi: 10.1007/s10787-025-01751-9.

DOI:10.1007/s10787-025-01751-9

PMID:40263172

Abstract

Cancer remains the leading cause of death worldwide. The treatment of cancer has become increasing complex. Current treatment options for cancer include surgical resection, chemotherapy, radiotherapy, nanomedicine, and immunotherapy. Recent experimental and clinical studies have provided substantial evidence supporting the potential use of melatonin as a preventive and therapeutic agent in oncology. Melatonin (N-acetyl-5-methoxy-tryptamine), a pleiotropic and multitasking molecule, is secreted from the pineal gland during the night under normal light-dark conditions. Beyond its role in circadian regulation, melatonin exhibits antioxidant, anti-aging, immunomodulatory, and anti-cancer properties. Melatonin exerts significant apoptotic, angiogenic, oncostatic, and anti-proliferative effects on a variety of cancer cells. This review discusses the influence of melatonin on cancer cells through mechanisms involving cell cycle regulation, stimulation of apoptosis, autophagy induction, epigenetic modification, and transcriptional regulation.

摘要

癌症仍然是全球主要的死因。癌症的治疗变得越来越复杂。目前癌症的治疗选择包括手术切除、化疗、放疗、纳米医学和免疫疗法。最近的实验和临床研究提供了大量证据，支持褪黑素在肿瘤学中作为预防和治疗药物的潜在用途。褪黑素（N-乙酰基-5-甲氧基色胺）是一种具有多种功能的多任务分子，在正常的明暗条件下，夜间由松果体分泌。除了在昼夜节律调节中的作用外，褪黑素还具有抗氧化、抗衰老、免疫调节和抗癌特性。褪黑素对多种癌细胞具有显著的凋亡、血管生成抑制、肿瘤抑制和抗增殖作用。本文综述了褪黑素通过细胞周期调控、诱导凋亡、自噬诱导、表观遗传修饰和转录调控等机制对癌细胞的影响。