1 The Second Clinical Medical School of Nanchang University , Nanchang, China .
2 The Fourth Clinical Medical School of Nanchang University , Nanchang, China .
J Interferon Cytokine Res. 2018 Sep;38(9):370-377. doi: 10.1089/jir.2018.0075.
Recently, the relationship between functional interleukin-6 (IL-6) polymorphisms and coronary artery disease (CAD) was extensively studied, with controversial findings. Therefore, we conducted this meta-analysis to better elucidate the relationship between these polymorphisms and the risk of CAD. A total of 57 case-control studies were finally included. The overall analyses showed that IL-6 -174G>C and -572G>C polymorphisms were significantly associated with the risk of CAD, the C allele of -174G>C (G versus C, odds ratio [OR] = 0.82, confidence interval [95% CI] = 0.75-0.89) and -572G>C polymorphisms (G versus C, OR = 0.82, 95% CI = 0.74-0.92) conferred an increased susceptibility to CAD. Further subgroup analyses yielded similar positive results for -174G>C polymorphism in Asian and Caucasian populations, and for -572G>C polymorphism in Asian and African populations. In conclusion, our findings suggest that IL-6 -174G>C and -572G>C polymorphisms may serve as potential genetic markers of CAD.
最近，人们广泛研究了功能性白细胞介素-6（IL-6）多态性与冠心病（CAD）之间的关系，但研究结果存在争议。因此，我们进行了这项荟萃分析，以更好地阐明这些多态性与 CAD 风险之间的关系。最终共纳入了 57 项病例对照研究。总体分析表明，IL-6-174G>C 和-572G>C 多态性与 CAD 风险显著相关，-174G>C（G 对 C，比值比[OR] = 0.82，95%置信区间[95% CI] = 0.75-0.89）和-572G>C 多态性（G 对 C，OR = 0.82，95% CI = 0.74-0.92）的 C 等位基因增加了 CAD 的易感性。亚组分析进一步得出了相似的阳性结果，即在亚洲和高加索人群中-174G>C 多态性，以及在亚洲和非洲人群中-572G>C 多态性。总之，我们的研究结果表明，IL-6-174G>C 和-572G>C 多态性可能是 CAD 的潜在遗传标志物。
