白细胞介素-6基因多态性（174G>C和572C>G）对冠状动脉疾病的影响：一项系统评价和荟萃分析。
The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis.
作者信息
Salari Nader, Mansouri Kamran, Hosseinian-Far Amin, Ghasemi Hooman, Mohammadi Masoud, Jalali Rostam, Vaisi-Raygani Aliakbar
机构信息
Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Genes Environ. 2021 Jan 12;43(1):1. doi: 10.1186/s41021-021-00172-8.
BACKGROUND
Coronary Artery Disease (CAD) is caused by the blockage of the coronary arteries. it is argued that there has an association between the Interleukin-6 gene and the occurrence of atherosclerosis, coronary artery disease, Due to the short half-life and high variability of Interleukin-6 (IL-6), limited studies have been performed on the association of serum levels of interleukin-6 with coronary artery disease. The aim of this study is to investigate the relationship between IL-6 gene polymorphisms and coronary artery disease.
METHODS
This study was conducted as a meta-analysis of selected articles with no lower time limit and upto March 2020. Articles related to the subject were obtained by searching several data sources,such as the SID, IranDoc, Scopus, Embase, Web of Science (ISI), PubMed, Science Direct, and Google Scholar databases. The heterogeneity of the studies was assessed using the I index in the Comprehensive Meta-Analysis software.
RESULTS
The GG genotype of the IL-6174 G> C polymorphism with a 0.8 odds ratio tended to reduce the risk of CAD by 20%. The odds ratio of CAD in CG and GG genotypes were found to be 1.16 and 1.48 times respectively, indicating the increasing effect of these two genotypes. In the IL-6-572 C>G polymorphism, CG and GG genotypes increased the risk of CAD by 1.21 and 1.27 times respectively, and the CC genotype tended to reduce the risk of CAD by 15%, considering the odds ratio of 0.85.
CONCLUSION
This study showed a relationship between IL-6174G> C and Interleukin-6 (IL-6) 572 C>G genes and coronary artery disease. Moreover, the protective effects of GG genotype in IL-6 gene 174 G> C and CC genotype in IL-6 gene 572 C>G gene were reported. The study also confirmed that the CG and CC genotypes of the G>C IL-6174 gene have an increasing effect on coronary artery disease. Moreover, CG and GG genotypes in the IL-6 gene 572 C>G increased the risk of developing CAD. It should be noted that the increased risk of developing CAD was limited to meta-analytic studies in reported literatures.
背景
冠状动脉疾病（CAD）是由冠状动脉阻塞引起的。有人认为白细胞介素-6基因与动脉粥样硬化、冠状动脉疾病的发生之间存在关联。由于白细胞介素-6（IL-6）半衰期短且变异性高，关于血清白细胞介素-6水平与冠状动脉疾病关联的研究有限。本研究的目的是探讨IL-6基因多态性与冠状动脉疾病之间的关系。
方法
本研究作为对所选文章的荟萃分析进行，时间无下限直至2020年3月。通过搜索多个数据源，如SID、IranDoc、Scopus、Embase、科学网（ISI）、PubMed、Science Direct和谷歌学术数据库，获取与该主题相关的文章。使用综合荟萃分析软件中的I指数评估研究的异质性。
结果
IL-6 174 G>C多态性的GG基因型，优势比为0.8，倾向于使CAD风险降低20%。发现CG和GG基因型的CAD优势比分别为1.16倍和1.48倍，表明这两种基因型有增加风险的作用。在IL-6 -572 C>G多态性中，CG和GG基因型分别使CAD风险增加1.21倍和1.27倍，考虑到优势比为0.85，CC基因型倾向于使CAD风险降低15%。
结论
本研究表明IL-6 174G>C和白细胞介素-6（IL-6）572 C>G基因与冠状动脉疾病之间存在关联。此外，报告了IL-6基因174 G>C中的GG基因型和IL-6基因572 C>G基因中的CC基因型的保护作用。该研究还证实，IL-6 174基因的G>C的CG和CC基因型对冠状动脉疾病有增加风险的作用。此外，IL-6基因572 C>G中的CG和GG基因型增加了患CAD的风险。需要注意的是，患CAD风险增加仅限于已报道文献中的荟萃分析研究。
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