Lavergne Marion, Janus-Bell Emily, Schaff Mathieu, Gachet Christian, Mangin Pierre H
Université de Strasbourg, INSERM, EFS Grand-Est, BPPS UMR-S 949, FMTS, F-67000 Strasbourg, France.
Cancers (Basel). 2017 Sep 28;9(10):133. doi: 10.3390/cancers9100133.
Platelets are small anucleated cell fragments that ensure the arrest of bleeding after a vessel wall injury. They are also involved in non-hemostatic function such as development, immunity, inflammation, and in the hematogeneous phase of metastasis. While the role of platelets in tumor metastasis has been recognized for 60 years, the molecular mechanism underlying this process remains largely unclear. Platelets physically and functionally interact with various tumor cells through surface receptors including integrins. Platelets express five integrins at their surface, namely α2β1, α5β1, α6β1, αvβ3, and αIIbβ3, which bind preferentially to collagen, fibronectin, laminin, vitronectin, and fibrinogen, respectively. The main role of platelet integrins is to ensure platelet adhesion and aggregation at sites of vascular injury. Two of these, α6β1 and αIIbβ3, were proposed to participate in platelet-tumor cell interaction and in tumor metastasis. It has also been reported that pharmacological agents targeting both integrins efficiently reduce experimental metastasis, suggesting that platelet integrins may represent new anti-metastatic targets. This review focuses on the role of platelet integrins in tumor metastasis and discusses whether these receptors may represent new potential targets for novel anti-metastatic approaches.
血小板是无细胞核的小细胞碎片，可确保血管壁损伤后止血。它们还参与非止血功能，如发育、免疫、炎症以及转移的血行阶段。虽然血小板在肿瘤转移中的作用已被认识60年，但这一过程的分子机制仍 largely不清楚。血小板通过包括整合素在内的表面受体与各种肿瘤细胞在物理和功能上相互作用。血小板表面表达五种整合素，即α2β1、α5β1、α6β1、αvβ3和αIIbβ3，它们分别优先结合胶原蛋白、纤连蛋白、层粘连蛋白、玻连蛋白和纤维蛋白原。血小板整合素的主要作用是确保血小板在血管损伤部位的黏附和聚集。其中两种，α6β1和αIIbβ3，被认为参与血小板 - 肿瘤细胞相互作用和肿瘤转移。也有报道称，针对这两种整合素的药物可有效减少实验性转移，这表明血小板整合素可能代表新的抗转移靶点。本综述重点关注血小板整合素在肿瘤转移中的作用，并讨论这些受体是否可能代表新型抗转移方法的新潜在靶点。
