Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops , Yangzhou University , Yangzhou 225009 , People's Republic of China.
Joint International Research Laboratory of Agriculture & Agri-Product Safety of Ministry of Education of China , Yangzhou University , Yangzhou 225009 , People's Republic of China.
J Agric Food Chem. 2018 Oct 10;66(40):10421-10430. doi: 10.1021/acs.jafc.8b03772. Epub 2018 Oct 2.
Nine new neolignan glycosides (1-9), viburfordosides A-I, two new neolignans, fordianes A and B (10, 11), and seven known analogues (12-18) have been isolated and identified from the fruits of Viburnum fordiae Hance. The structures and absolute configurations of undescribed neolignan constituents were identified by chemical methods and spectroscopic analyses. The α-glucosidase inhibitory, ABTS and DPPH scavenging, and anti-inflammatory activities of these secondary metabolites were evaluated. Some of them exhibited significant potency in inhibiting α-glucosidase and scavenging free radicals. Among the 14 metabolites that were found to have the capacity to inhibit NO production in LPS-stimulated RAW264.7 macrophage cells, compounds 2, 4, 6, 10, 11, 14, 17, and 18 were potent with IC values of 10.88-41.10 μM. These results support that V. fordiae fruits possessing the neolignan compounds may serve as both a functional food and a medicinal resource to prevent and treat type 2 diabetes (T2D).
从 Viburnum fordiae Hance 的果实中分离并鉴定出了 9 种新的木脂素糖苷（1-9），即 viburfordosides A-I，2 种新的木脂素，fordianes A 和 B（10、11），以及 7 种已知类似物（12-18）。通过化学方法和光谱分析鉴定了未描述的木脂素成分的结构和绝对构型。评估了这些次生代谢物的α-葡萄糖苷酶抑制、ABTS 和 DPPH 清除以及抗炎活性。其中一些化合物在抑制α-葡萄糖苷酶和清除自由基方面表现出显著的活性。在所发现的 14 种具有抑制 LPS 刺激的 RAW264.7 巨噬细胞细胞中 NO 产生能力的代谢物中，化合物 2、4、6、10、11、14、17 和 18 具有较强的抑制作用，IC 值为 10.88-41.10 μM。这些结果表明，V. fordiae 果实中含有木脂素化合物，可作为预防和治疗 2 型糖尿病（T2D）的功能性食品和药用资源。
