高敏C反应蛋白水平与支架内再狭窄的关联：一项病例对照研究。
Association of high level of hs-CRP with in-stent restenosis: A case-control study.
作者信息
Baktashian Mojtaba, Saffar Soflaei Sara, Kosari Negin, Salehi Mansoor, Khosravi Alireza, Ahmadinejad Maliheh, Moohebati Mohsen, Ebrahimi Mahmood, Rahmani Farzad, Khameneh-Bagheri Ramin, Ahmadi Mostafa, Sadabadi Fatemeh, Tayefi Maryam, Bazhdanzadeh Suzan, Ferns Gordon A, Hashemi Seyed Mohammad, Pasdar Alireza, Ghayour-Mobarhan Majid
机构信息
Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Cardiovasc Revasc Med. 2019 Jul;20(7):583-587. doi: 10.1016/j.carrev.2018.08.015. Epub 2018 Aug 18.
BACKGROUND
In-stent restenosis (ISR) is one adverse outcome of coronary stent implantation. Although using drug-eluting stents has reduced the rate of ISR, it remains a major problem. Here, we have investigated the relationship between several patient characteristics including serum high sensitive C-reactive protein (hs-CRP) and ISR.
METHODS
This was a case-control study comprising 104 individuals with ISR and 202 patients without. Baseline characteristics were collected using a questionnaire. Fasting blood glucose (FBG), serum triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and serum high sensitivity C-reactive protein (hs-CRP) were measured using commercial kits on an auto-analyzer. Data were analyzed using SPSS software and a p value ≤ 0.05 was considered significant.
RESULTS
Diabetes mellitus (p < 0.001), stent type (p = 0.005), serum hs-CRP (p = 0.006), FBG (p = 0.038) and serum TG (p = 0.039) were significantly associated with ISR. The association between hs-CRP and ISR remained significant after adjustment for stent type and DM. For patients with a serum hs-CRP <2.64 mg/dL, ISR was only associated with diabetes mellitus (p = 0.016); while for individuals with a serum hs-CRP ≥2.64 mg/dL, ISR was also associated with the presence of diabetes mellitus, serum triglycerides and stent type.
CONCLUSION
Higher levels of serum hs-CRP were significantly associated with the occurrence of ISR.
背景
支架内再狭窄（ISR）是冠状动脉支架植入术的一种不良后果。尽管使用药物洗脱支架降低了ISR的发生率，但它仍然是一个主要问题。在此，我们研究了包括血清高敏C反应蛋白（hs-CRP）在内的几种患者特征与ISR之间的关系。
方法
这是一项病例对照研究，包括104例ISR患者和202例无ISR患者。使用问卷收集基线特征。使用商用试剂盒在自动分析仪上测量空腹血糖（FBG）、血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和血清高敏C反应蛋白（hs-CRP）。使用SPSS软件分析数据，p值≤0.05被认为具有统计学意义。
结果
糖尿病（p<0.001）、支架类型（p=0.005）、血清hs-CRP（p=0.006）、FBG（p=0.038）和血清TG（p=0.039）与ISR显著相关。在调整支架类型和糖尿病后，hs-CRP与ISR之间的关联仍然显著。对于血清hs-CRP<2.64mg/dL的患者，ISR仅与糖尿病相关（p=0.016）；而对于血清hs-CRP≥2.64mg/dL的个体，ISR还与糖尿病、血清甘油三酯和支架类型的存在相关。
结论
血清hs-CRP水平升高与ISR的发生显著相关。
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