Wang Zhihong, Sheng Lei, Gu Hongbin, Yang Fan, Xie Huajie, Li Mingfei
Department of Vascular Intervention, People's Liberation Army Strategic Support Force Characteristic Medical Center, Beijing, China.
Front Cardiovasc Med. 2022 Jul 14;9:868656. doi: 10.3389/fcvm.2022.868656. eCollection 2022.
Peripheral artery disease (PAD) is a common atherosclerotic vascular disease. The use of drug-coated balloon (DCB) for the treatment of femoropopliteal artery disease has gradually increased. A certain percentage of patients developed target lesion restenosis after DCB treatment of the femoral popliteal artery. The neutrophil-to-lymphocyte ratio (NLR) is closely related to the level of inflammatory activity and has predictive value for atherosclerotic vascular disease. This study aimed to analyze the relationship between NLR and 1-year restenosis after DCB for femoropopliteal artery disease.
Patients with femoropopliteal artery disease who were treated with DCBs at our hospital from May 2016 to December 2020 were retrospectively included. Baseline data during the patient's first hospital stay and data during follow-up were collected. Demographic data, laboratory test results, lesion examination results, and major adverse events during the follow-up period were collected. Logistic regression was used to analyze the factors associated with restenosis after DCB.
A total of 117 patients were included. During 1-year follow-up, 19 cases (16.2%) of restenosis were detected. Five of these patients (4.3% of total included patients) were readmitted for symptomatic ischemia. No deaths or amputations occurred. Baseline NLR in patients with restenosis was higher than that in patients without restenosis (2.4 (2.1, 3.4) vs. 1.8 (1.3, 2.3), < 0.001). Logistic univariate and multivariate analysis showed that baseline hs-CRP level (OR = 1.10, 95%CI: 1.05-1.34), lesion length (OR = 1.04, 95%CI: 1.02-1.27), use of rivaroxaban (OR = 1.08, 95%CI: 1.05-1.39), NLR (OR = 1.47, 95%CI: 1.13-2.48), LDL-C level (OR = 1.25, 95%CI: 1.05-1.52), and diabetes (OR = 1.25, 95%CI: 1.05-1.52) = 1.18, 95%CI: 1.06-1.66) were predictors of restenosis.
Baseline NLR before DCB can predict the risk of restenosis after surgery.
外周动脉疾病（PAD）是一种常见的动脉粥样硬化性血管疾病。药物涂层球囊（DCB）用于治疗股腘动脉疾病的应用逐渐增多。一定比例的患者在DCB治疗股腘动脉后发生靶病变再狭窄。中性粒细胞与淋巴细胞比值（NLR）与炎症活动水平密切相关，对动脉粥样硬化性血管疾病具有预测价值。本研究旨在分析NLR与DCB治疗股腘动脉疾病后1年再狭窄之间的关系。
回顾性纳入2016年5月至2020年12月在我院接受DCB治疗的股腘动脉疾病患者。收集患者首次住院期间的基线数据和随访期间的数据。收集人口统计学数据、实验室检查结果、病变检查结果以及随访期间的主要不良事件。采用逻辑回归分析DCB术后再狭窄的相关因素。
共纳入117例患者。在1年随访期间，检测到19例（16.2%）再狭窄。其中5例患者（占纳入患者总数的4.3%）因症状性缺血再次入院。未发生死亡或截肢。再狭窄患者的基线NLR高于无再狭窄患者（2.4（2.1，3.4）对1.8（1.3，2.3），<0.001）。逻辑单因素和多因素分析显示，基线hs-CRP水平（OR = 1.10，95%CI：1.05 - 1.34）、病变长度（OR = 1.04，95%CI：1.02 - 1.27）、利伐沙班的使用（OR = 1.08，95%CI：1.05 - 1.39）、NLR（OR = 1.47，95%CI：1.13 - 2.48）、LDL-C水平（OR = 1.25，95%CI：1.05 - 1.52）和糖尿病（OR = 1.18，95%CI：1.06 - 1.66）是再狭窄的预测因素。
DCB术前的基线NLR可预测术后再狭窄风险。
