Department of Physical & Rehabilitation Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, The Republic of Korea.
Department of Rehabilitation Medicine, Graduate School of Medicine, Chung-Ang University, Seoul, Korea.
BMJ Open. 2018 Sep 19;8(9):e021232. doi: 10.1136/bmjopen-2017-021232.
To evaluate the association between high-sensitivity C-reactive protein (hs-CRP) and sarcopenic obesity, and to determine age or sex differences underlying the relationship between hs-CRP and sarcopenic obesity.
Observational study.
The study included 237 838 participants whose body composition and hs-CRP were analysed at the two health promotion centres in South Korea. Participants were divided into four groups based on body composition: normal, obesity only, sarcopenia only and sarcopenic obesity.
The levels of hs-CRP and proportion of participants with high (≥1.0 mg/L) hs-CRP. Sarcopenic obesity was defined as subjects fulfilling the criteria for sarcopenia (below 2 SD of mean of Skeletal Muscle Mass Index for young adults) and obesity (waist circumference ≥90 cm for men and ≥85 cm for women).
The level of hs-CRP was highest in the sarcopenic obesity group. Following adjustment for various confounders including age, sex, comorbidities, metabolic, health-related behaviour and demographic factors, the adjusted ORs (95% CI) for subjects with high hs-CRP associated with obesity, sarcopenia and sarcopenic obesity compared with normal group (reference) were 1.17 (1.05 to 1.31), 2.23 (1.21 to 4.07) and 3.23 (2.71 to 3.83), respectively. In age subgroup analyses, multivariate logistic regression analysis revealed that the association of high hs-CRP with sarcopenic obesity was stronger in younger (<60 years) participants than in older (≥60 years) participants (p for interaction <0.001). In subgroup analyses for sex, the association of high hs-CRP with sarcopenic obesity was higher in female participants than in males (p for interaction <0.001).
This study demonstrated that high level of hs-CRP was independently associated with sarcopenic obesity in Korean population. We found for the first time that there was a strong association between increased hs-CRP and sarcopenic obesity in female and younger (<60 years) subjects.
评估高敏 C 反应蛋白（hs-CRP）与肌少症性肥胖的相关性，并确定 hs-CRP 与肌少症性肥胖之间关系的年龄或性别差异。
观察性研究。
本研究纳入了在韩国的两个健康促进中心进行身体成分和 hs-CRP 分析的 237838 名参与者。根据身体成分，参与者分为四组：正常组、单纯肥胖组、单纯肌少症组和肌少症性肥胖组。
hs-CRP 水平和 hs-CRP 水平升高（≥1.0mg/L）的参与者比例。肌少症性肥胖定义为符合肌少症标准（年轻人骨骼肌质量指数低于 2 个标准差）和肥胖标准（男性腰围≥90cm，女性腰围≥85cm）的受试者。
hs-CRP 水平在肌少症性肥胖组最高。在调整了年龄、性别、合并症、代谢、健康相关行为和人口统计学因素等各种混杂因素后，与正常组（参照组）相比，hs-CRP 升高与肥胖、肌少症和肌少症性肥胖相关的调整后比值比（95%CI）分别为 1.17（1.05 至 1.31）、2.23（1.21 至 4.07）和 3.23（2.71 至 3.83）。在年龄亚组分析中，多变量逻辑回归分析显示，hs-CRP 升高与肌少症性肥胖的相关性在年轻（<60 岁）参与者中强于在老年（≥60 岁）参与者中（交互作用 P<0.001）。在性别亚组分析中，hs-CRP 升高与肌少症性肥胖的相关性在女性参与者中高于男性（交互作用 P<0.001）。
本研究表明，在韩国人群中，高水平的 hs-CRP 与肌少症性肥胖独立相关。我们首次发现，在女性和年轻（<60 岁）参与者中，hs-CRP 升高与肌少症性肥胖之间存在较强的关联。
