Kim Eunsoo, Jung Sra, Lee Mi Yeon, Park Chul-Hyun, Cho Sung Joon
Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Republic of Korea.
Department of Psychiatry, Cha University Ilsan Medical Center, Goyang 10223, Republic of Korea.
Brain Sci. 2024 Apr 28;14(5):438. doi: 10.3390/brainsci14050438.
Individuals with mental health problems are at higher risk of musculoskeletal diseases. However, the association between low muscle mass (LMM) and anxiety symptoms remains uninvestigated. This cross-sectional study enrolled 174,262 adults (73,833 women, 100,429 men), aged 18 to 89, who completed the anxiety scale and body composition analyses. Using bio-electrical impedance analysis, skeletal muscle mass index (SMI) was calculated based on appendicular skeletal muscle mass (ASM) (kg)/height (m). LMM was defined as SMI < 7.0 kg/m in men and <5.4 kg/m in women. Anxiety symptoms were screened using the Clinical Useful Anxiety Outcome Scale (CUXOS) with cut-off scores of 20, 30, and 40. Multivariable logistic regression analyses were performed. LMM prevalence was 20.17% in women, 3.86% in men ( < 0.001). The prevalence of anxiety symptoms in LMM group decreased from mild (CUXOS > 20: women, 32.74%, men, 21.17%) to moderate (CUXOS > 30: 13.34%, 7.32%), to severe anxiety symptoms (CUXOS > 40: 4.00%, 1.73%). In multivariable-adjusted models, LMM was associated with mild (aOR (95% confidence interval)), women, 1.13 (1.08-1.17); men, 1.17 (1.08-1.27)), moderate (1.17 (1.11-1.24); 1.35 (1.19-1.53) and severe anxiety symptoms (1.18 (1.07-1.3), 1.36 (1.06-1.74)), demonstrating an increased risk of ORs with escalating anxiety severity. LMM was independently associated with a higher prevalence of anxiety symptoms.
有心理健康问题的个体患肌肉骨骼疾病的风险更高。然而，低肌肉量（LMM）与焦虑症状之间的关联仍未得到研究。这项横断面研究纳入了174262名年龄在18至89岁之间的成年人（73833名女性，100429名男性），他们完成了焦虑量表和身体成分分析。使用生物电阻抗分析，根据四肢骨骼肌质量（ASM）（kg）/身高（m）计算骨骼肌质量指数（SMI）。LMM定义为男性SMI<7.0kg/m，女性<5.4kg/m。使用临床有用焦虑结果量表（CUXOS）筛查焦虑症状，临界值分别为20、30和40。进行了多变量逻辑回归分析。女性LMM患病率为20.17%，男性为3.86%（<0.001）。LMM组焦虑症状的患病率从轻度（CUXOS>20：女性为32.74%，男性为21.17%）降至中度（CUXOS>30：13.34%，7.32%），再降至重度焦虑症状（CUXOS>40：4.00%，1.73%）。在多变量调整模型中，LMM与轻度（aOR（95%置信区间））、女性1.13（1.08 - 1.17）；男性1.17（1.08 - 1.27））、中度（1.17（1.11 - 1.24）；1.35（1.19 - 1.53））和重度焦虑症状（1.18（1.07 - 1.3），1.36（1.06 - 1.74））相关，表明随着焦虑严重程度的增加，OR值风险增加。LMM与焦虑症状的较高患病率独立相关。
