Department of Neurosurgery, The First Center Hospital of Tianjin, Tianjin Medical University First Center Clinical College, Tianjin 300192, P.R. China.
Department of Family Medicine, Tianjin United Family Hospital, Tianjin 300221, P.R. China.
Biosci Rep. 2018 Oct 17;38(5). doi: 10.1042/BSR20180942. Print 2018 Oct 31.
In the present study, we aimed at determining the potential role of rs12917 polymorphism of the -6-methylguanine-DNA methyltransferase () gene in the occurrence of cancer. Based on the available data from the online database, we performed an updated meta-analysis. We retrieved 537 articles from our database research and finally selected a total of 54 case-control studies (21010 cases and 34018 controls) for a series of pooling analyses. We observed an enhanced risk in cancer cases compared with controls, using the genetic models T/T compared with C/C (-value of association test <0.001; odds ratio (OR) = 1.29) and T/T compared with C/C+C/T (<0.001; OR = 1.32). We detected similar positive results in the subgroups 'Caucasian', and 'glioma' (all <0.05; OR > 1). However, we detected negative results in our analyses of most of the other subgroups (>0.05). Begg's and Egger's tests indicated that the results were free of potential publication bias, and sensitivity analysis suggested the stability of the pooling results. In summary, the T/T rs12917 is likely to be linked to an enhanced susceptibility to cancer overall, especially glioma, in the Caucasian population.
在本研究中，我们旨在确定 rs12917 多态性在癌症发生中的潜在作用。基于在线数据库中的现有数据，我们进行了更新的荟萃分析。我们从数据库研究中检索到 537 篇文章，最终选择了总共 54 项病例对照研究（21010 例病例和 34018 例对照）进行一系列汇总分析。我们观察到与对照组相比，癌症病例存在风险增加，使用遗传模型 T/T 与 C/C 相比（关联检验值<0.001；优势比（OR）=1.29）和 T/T 与 C/C+C/T 相比（<0.001；OR=1.32）。我们在“高加索人”和“神经胶质瘤”亚组中检测到类似的阳性结果（均<0.05；OR>1）。然而，我们在对大多数其他亚组的分析中检测到阴性结果（>0.05）。Begg 和 Egger 检验表明结果无潜在发表偏倚，敏感性分析表明汇总结果稳定。总之，T/T rs12917 可能与高加索人群总体癌症易感性增加有关，尤其是神经胶质瘤。
