Amemiya T, Yoshida H
J Pediatr Ophthalmol. 1977 Jul-Aug;14(4):242-7.
The orbital bone lesion of a patient with Hand-Schüller-Christian disease was examined by electron microscopy. Vacuoles in the cytoplasm of foam cells contained granules which were shown by histochemical examination to be cholesterin. Langerhans cell granules in the histiocytes of Hand-Schüller-Christian disease showed a close resemblance to those in Langerhans cell of the epidermis, eosinophilic granuloma and Letterer-Siwe disease. Charcot-Leyden crystals appeared to be formed in the lysosomes of histiocytes in Hand-Schüller-Christian disease. From histopathological and cytological points of view, eosinophilic granuloma, Hand-Schüller-Christian disease and Letterer-Siwe disease are classified as histiocytosis X. The simultaneous appearance of Langerhans cell granules and Charcot-Leyden crystals is specific in histiocytosis X.
对一名患有汉-许-克病的患者的眼眶骨病变进行了电子显微镜检查。泡沫细胞胞质中的空泡含有颗粒，组织化学检查显示这些颗粒为胆固醇。汉-许-克病组织细胞中的朗格汉斯细胞颗粒与表皮、嗜酸性肉芽肿和勒-雪病的朗格汉斯细胞颗粒极为相似。在汉-许-克病的组织细胞溶酶体中似乎形成了夏科-莱登结晶。从组织病理学和细胞学角度来看，嗜酸性肉芽肿、汉-许-克病和勒-雪病被归类为组织细胞增生症X。朗格汉斯细胞颗粒和夏科-莱登结晶同时出现是组织细胞增生症X的特征。
