Children's Health Research Center, Changzhou Children's Hospital, Changzhou, China.
Institut National de Recherche en Informatique et en Automatique (INRIA), Saclay, France.
Neurol India. 2018 Sep-Oct;66(5):1359-1364. doi: 10.4103/0028-3886.241334.
To determine the characteristics of brain development in children with nocturnal enuresis, we investigated the intensity of functional connectivity both among the nodes in the brain network and between the two hemispheres of the brain.
Twenty-three children with nocturnal enuresis (NE) and an equal number of normal children were examined using resting-state functional magnetic resonance imaging (fMRI) scans. Data analysis was done via the degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) approaches. Moreover, we compared the children's psychological status by utilizing the self-concept scale.
In four areas of the brain, the the DC values of the NE group were obviously lower than that of the normal controls. These four areas were the posterior cerebellar lobe, anterior cingulate cortex (ACC), medial frontal gyrus, and superior left temporal gyrus (P < 0.05, after correction). We also found two brain areas where the VMHC values of the NE group were obviously lower than that of the normal controls. The two groups were the cerebellar lobe and the anterior cingulate cortex (ACC) [P < 0.05, after correction]. A psychological comparison between the children with NE and that in the normal group on the self-concept scale was also performed. The scores of the children with NE were lower than normal controls regarding behavior, appearance and property, anxiety, gregariousness, happiness, and satisfaction (P < 0.05).
These findings provide evidence of the deficit of urination control in children with NE. Furthermore, through the methods of DC and VMHC, which are based on functional connectivity, it was also possible to explain why children with NE often have the concomitant symptoms of attention, control, and memory problems. The analysis of the self-concept scale suggests that children with NE lack self-confidence.
通过研究脑网络节点间和大脑两半球间功能连接的强度，确定遗尿症患儿脑发育的特点。
采用静息态功能磁共振成像（fMRI）对 23 例遗尿症（NE）患儿和 23 名正常儿童进行检查。采用度中心度（DC）和体素镜像同伦连接（VMHC）方法进行数据分析。此外，我们利用自我概念量表比较了两组儿童的心理状况。
在大脑的四个区域，NE 组的 DC 值明显低于正常对照组。这四个区域分别是后小脑叶、前扣带回皮质（ACC）、内侧额回和左上颞叶（P < 0.05，校正后）。我们还发现 NE 组的两个脑区 VMHC 值明显低于正常对照组。两组分别为小脑叶和前扣带回皮质（ACC）[P < 0.05，校正后]。我们还对遗尿症患儿与正常组在自我概念量表上的心理状况进行了比较。遗尿症患儿的行为、外貌和财产、焦虑、合群、幸福和满意度评分均低于正常对照组（P < 0.05）。
这些发现为遗尿症患儿排尿控制缺陷提供了证据。此外，通过基于功能连接的 DC 和 VMHC 方法，还可以解释为什么遗尿症患儿常伴有注意力、控制和记忆问题的伴随症状。自我概念量表的分析表明，遗尿症患儿缺乏自信。
