Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong-Fang Road, Shanghai, 200127, China.
School of Information and Electronics Technology, Jiamusi University, Jiamusi, Heilongjiang, China.
Sci Rep. 2021 Jun 8;11(1):12042. doi: 10.1038/s41598-021-90546-3.
Resting state functional magnetic resonance imaging studies of nocturnal enuresis have focused primarily on regional metrics in the blood oxygen level dependent (BOLD) signal ranging from 0.01 to 0.08 Hz. However, it remains unclear how local metrics show in sub-frequency band. 129 children with nocturnal enuresis (NE) and 37 healthy controls were included in this study. The patients were diagnosed by the pediatricians in Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, according to the criteria from International Children's Continence Society (ICCS). Questionnaires were used to evaluate the symptoms of enuresis and completed by the participants. In this study, fALFF, ReHo and PerAF were calculated within five different frequency bands: typical band (0.01-0.08 Hz), slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz), and slow-2 (0.198-0.25 Hz). In the typical band, ReHo increased in the left insula and the right thalamus, while fALFF decreased in the right insula in children with NE. Besides, PerAF was increased in the right middle temporal gyrus in these children. The results regarding ReHo, fALFF and PerAF in the typical band was similar to those in slow-5 band, respectively. A correlation was found between the PerAF value of the right middle temporal gyrus and scores of the urinary intention-related wakefulness. Results in other bands were either negative or in white matter. NE children might have abnormal intrinsic neural oscillations mainly on slow-5 bands.
静息态功能磁共振成像研究主要集中在血氧水平依赖（BOLD）信号的局部指标上，频率范围在 0.01 到 0.08 Hz 之间。然而，局部指标在亚频带中如何表现尚不清楚。本研究纳入了 129 例遗尿症（NE）患儿和 37 例健康对照。这些患儿由上海交通大学医学院附属上海儿童医学中心的儿科医生根据国际儿童尿控协会（ICCS）的标准诊断。问卷调查用于评估遗尿症状，并由参与者完成。在这项研究中，在五个不同的频率带内计算了 fALFF、ReHo 和 PerAF：典型带（0.01-0.08 Hz）、慢-5（0.01-0.027 Hz）、慢-4（0.027-0.073 Hz）、慢-3（0.073-0.198 Hz）和慢-2（0.198-0.25 Hz）。在典型带中，NE 患儿的左侧岛叶和右侧丘脑的 ReHo 增加，而右侧岛叶的 fALFF 减少。此外，这些患儿的右侧颞中回的 PerAF 增加。典型带中 ReHo、fALFF 和 PerAF 的结果分别与慢-5 带的结果相似。右侧颞中回的 PerAF 值与尿意觉醒评分呈正相关。其他带的结果要么为负，要么在白质中。NE 患儿可能存在异常的内在神经振荡，主要集中在慢-5 频段。
