Roulot Morgane, Minelli Alessandra, Bortolomasi Marco, Maffioletti Elisabetta, Gennarelli Massimo, Borsotto Marc, Heurteaux Catherine, Mazella Jean
Molecular and Cellular Institute of Pharmacology, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 7275, Université Côte d'Azur, Valbonne, France,
Department of Molecular and Translational Medicine, Biology and Genetic Division, University of Brescia, Brescia, Italy.
Neuropsychiatr Dis Treat. 2018 Sep 6;14:2307-2312. doi: 10.2147/NDT.S170165. eCollection 2018.
Sortilin-derived propeptide (PE) and its synthetic analog spadin show strong antidepressant activity in rodents and, therefore, could be used as a biomarker to evaluate the clinical efficacy of antidepressant treatments. The aim of this study was to determine whether electroconvulsive therapy (ECT) modulates serum PE concentration in patients with treatment-resistant depression (TRD).
Forty-five patients with major depressive disorder, who met the criteria, were selected for this study.
We did not observe any difference in the PE levels between TRD patients and controls (=0.10, =0.92), but we found a strong significant increase between the PE levels measured just before (T0) and about 1 month (T2) after ECT (=-2.82, =0.005). A significant difference between T0 and T2 was observed only in responders (=-2.59, =0.01), whereas no effect was found in nonresponders (=-1.27, =0.20). Interestingly, we found a significant correlation between the increase in PE levels and decrease in Montgomery -Åsberg Depression Rating Scale scores for the total patient sample (=0.03).
This study indicates for the first time that ECT affects serum PE concentration in responders and, therefore, could contribute to the evaluation of the therapy success.
Sortilin衍生的前肽（PE）及其合成类似物spadin在啮齿动物中显示出强大的抗抑郁活性，因此可作为评估抗抑郁治疗临床疗效的生物标志物。本研究的目的是确定电休克疗法（ECT）是否能调节难治性抑郁症（TRD）患者的血清PE浓度。
选取45例符合标准的重度抑郁症患者进行本研究。
我们未观察到TRD患者与对照组之间的PE水平有任何差异（P=0.10，P=0.92），但我们发现ECT前（T0）和ECT后约1个月（T2）测得的PE水平之间有显著升高（P=-2.82，P=0.005）。仅在有反应者中观察到T0和T2之间存在显著差异（P=-2.59，P=0.01），而在无反应者中未发现影响（P=-1.27，P=0.20）。有趣的是，我们发现总患者样本中PE水平的升高与蒙哥马利-阿斯伯格抑郁评定量表评分的降低之间存在显著相关性（P=0.03）。
本研究首次表明ECT会影响有反应者的血清PE浓度，因此有助于评估治疗效果。
