Pan Yuhong, Li Pengfei, Jia Renyong, Wang Mingshu, Yin Zhongqiong, Cheng Anchun
Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Front Microbiol. 2018 Sep 4;9:2086. doi: 10.3389/fmicb.2018.02086. eCollection 2018.
Apoptosis, an indispensable innate immune mechanism, regulates cellular homeostasis by removing unnecessary or damaged cells. It contains three signaling pathways: the mitochondria-mediated pathway, the death receptor pathway and the endoplasmic reticulum pathway. The importance of apoptosis in host defenses is stressed by the observation that multiple viruses have evolved various strategies to inhibit apoptosis, thereby blunting the host immune responses and promoting viral propagation. Porcine Circovirus type 2 (PCV2) utilizes various strategies to induce or inhibit programmed cell death. In this article, we review the latest research progress of the apoptosis mechanisms during infection with PCV2, including several proteins of PCV2 regulate apoptosis via interacting with host proteins and multiple signaling pathways involved in PCV2-induced apoptosis, which provides scientific basis for the pathogenesis and prevention of PCV2.
细胞凋亡是一种不可或缺的固有免疫机制，通过清除不必要或受损的细胞来调节细胞内环境稳定。它包含三条信号通路：线粒体介导的通路、死亡受体通路和内质网通路。多种病毒已进化出各种策略来抑制细胞凋亡，从而削弱宿主免疫反应并促进病毒传播，这一现象凸显了细胞凋亡在宿主防御中的重要性。猪圆环病毒2型（PCV2）利用多种策略诱导或抑制程序性细胞死亡。在本文中，我们综述了PCV2感染过程中凋亡机制的最新研究进展，包括PCV2的几种蛋白通过与宿主蛋白相互作用来调节凋亡以及参与PCV2诱导凋亡的多条信号通路，这为PCV2的发病机制和预防提供了科学依据。
