Key Laboratory for Zoonoses Research, Ministry of Education, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun 130062, China.
Viruses. 2022 Jun 28;14(7):1419. doi: 10.3390/v14071419.
Porcine circoviruses (PCVs), including PCV1 to PCV4, are non-enveloped DNA viruses with a diameter of about 20 nm, belonging to the genus in the family . PCV2 is an important causative agent of porcine circovirus disease or porcine circovirus-associated disease (PCVD/PCVAD), which is highly prevalent in pigs and seriously affects the swine industry globally. Furthermore, PCV2 mainly causes subclinical symptoms and immunosuppression, and PCV3 and PCV4 were detected in healthy pigs, sick pigs, and other animals. Although the pathogenicity of PCV3 and PCV4 in the field is still controversial, the infection rates of PCV3 and PCV4 in pigs are increasing. Moreover, PCV3 and PCV4 rescued from infected clones were pathogenic in vivo. It is worth noting that the interaction between virus and host is crucial to the infection and pathogenicity of the virus. This review discusses the latest research progress on the molecular mechanism of PCVs-host interaction, which may provide a scientific basis for disease prevention and control.
猪圆环病毒（PCVs）包括 PCV1 至 PCV4，是一种无包膜的 DNA 病毒，直径约 20nm，属于Circoviridae 科Circovirus 属。PCV2 是猪圆环病毒病或猪圆环病毒相关疾病（PCVD/PCVAD）的重要病原体，在猪中高度流行，严重影响全球养猪业。此外，PCV2 主要引起亚临床症状和免疫抑制，而 PCV3 和 PCV4 则在健康猪、病猪和其他动物中被检测到。虽然 PCV3 和 PCV4 在现场的致病性仍存在争议，但猪中 PCV3 和 PCV4 的感染率正在增加。此外，从感染克隆中拯救出的 PCV3 和 PCV4 在体内具有致病性。值得注意的是，病毒与宿主之间的相互作用对病毒的感染和致病性至关重要。本综述讨论了 PCVs-宿主相互作用的分子机制的最新研究进展，这可能为疾病的预防和控制提供科学依据。
