Lefkowitz R J, Caron M G
J Mol Cell Cardiol. 1986 Sep;18(9):885-95. doi: 10.1016/s0022-2828(86)80003-7.
The various subtypes of adrenergic receptors represent distinct structural entities which are coupled in different ways to two major transmembrane signalling systems, the adenylate cyclase and phosphatidyl-inositol pathways. Recent evidence suggests that the functional linkage of both beta and alpha 1-adrenergic receptors to their respective effector systems is regulated by covalent modification of the receptors by phosphorylation-dephosphorylation reactions. Receptor phosphorylation appears to lead to desensitization of the biological response to receptor stimulation. Several kinases including protein kinase A, protein kinase C and a cAMP independent kinase appear to participate in these reactions.
肾上腺素能受体的各种亚型代表不同的结构实体，它们以不同方式与两种主要的跨膜信号系统（腺苷酸环化酶和磷脂酰肌醇途径）偶联。最近的证据表明，β和α1肾上腺素能受体与其各自效应系统的功能联系是通过磷酸化-去磷酸化反应对受体进行共价修饰来调节的。受体磷酸化似乎导致对受体刺激的生物学反应脱敏。包括蛋白激酶A、蛋白激酶C和一种不依赖cAMP的激酶在内的几种激酶似乎参与了这些反应。
