Tochimoto Masataka, Watanabe Toru, Koyama Kazunori, Sadamura Karin, Iwaki Yoshitaka, Katoh Hideaki, Kawaguchi Masahiko, Tawaraya Kanae, Hosokawa Osamu, Yanagimoto Kunio
Dept. of Surgery, Yokohama Sakae Kyosai Hospital.
Gan To Kagaku Ryoho. 2018 Sep;45(9):1353-1355.
The patient was a 42-year-old man who presented with dysphagia.Upper gastrointestinal endoscopy revealed a protruding lesion in the lower thoracic esophagus.Pathological analysis of the lesion showed squamous cell carcinoma.Laboratory data showed leukocytosis(21,200/mL)despite no evidence of infection, and the serum levels of granulocyte colony-stimu- lating factor(G-CSF)were elevated to 283 pg/mL.We diagnosed him with esophageal squamous cell carcinoma(Lt, type 1, cT4N4M0, cStage IV a).After administering 2 courses of docetaxel plus cisplatin plus S-1(DCS)as neoadjuvant chemotherapy, the patient underwent surgery.The pathological diagnosis was pType 2, T2, N4, M0, pStage IV a. G-CSF immunostaining was positive in tumor cells.After the surgery, the number of leukocytes and serum G-CSF levels decreased to within normal limits.Adjuvant chemotherapy was administered.
患者为一名42岁男性，因吞咽困难就诊。上消化道内镜检查发现胸段食管下段有一隆起性病变。病变的病理分析显示为鳞状细胞癌。实验室检查数据显示，尽管没有感染证据，但白细胞增多（21,200/mL），且粒细胞集落刺激因子（G-CSF）血清水平升高至283 pg/mL。我们诊断他为食管鳞状细胞癌（左，1型，cT4N4M0，c期IV a）。给予2个疗程的多西他赛联合顺铂加S-1（DCS）作为新辅助化疗后，患者接受了手术。病理诊断为p2型，T2，N4，M0，p期IV a。肿瘤细胞G-CSF免疫染色呈阳性。手术后，白细胞数量和血清G-CSF水平降至正常范围内。给予了辅助化疗。
