连接人类肺癌和结核分枝杆菌的常见非编码RNA。
Linking common non-coding RNAs of human lung cancer and M. tuberculosis.
作者信息
Barh Debmalya, Tiwari Sandeep, Kumavath Ranjith N, Ghosh Preetam, Azevedo Vasco
机构信息
Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India.
Laboratorio de Genetica Celular e Molecular, Departamento de Biologia Geral, Instituto de Ciencias Biologicas (ICB), Universidade Federal de Minas Gerais, Pampulha, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Bioinformation. 2018 Jun 30;14(6):337-345. doi: 10.6026/97320630014337. eCollection 2018.
Lung cancer and pulmonary tuberculosis caused by Mycobacterium are two major causes of deaths worldwide. Tuberculosis linked lung cancer is known. However, the precise molecular mechanism of Mycobacterium associated increased risk of lung cancer is not understood. We report 45 common human miRNAs deregulated in both pulmonary tuberculosis and lung cancer. We show that sRNA_1096 and sRNA_1414 from M. tuberculosis have sequence homology with human mir-21. Hence, the potential role of these three small non-coding RNAs in rifampicin resistance in pulmonary tuberculosis is implied. Further, the linking of sRNA_1096 and sRNA_1414 from M. tuberculosis with the host lung tumorigenesis is inferred. Nonetheless, further analysis and validation is required to associate these three non-coding RNAs with Mycobacterium associated increased risk of lung cancer.
肺癌和由分枝杆菌引起的肺结核是全球范围内的两大主要死因。肺结核相关肺癌已为人所知。然而，分枝杆菌导致肺癌风险增加的确切分子机制尚不清楚。我们报告了45种在肺结核和肺癌中均失调的常见人类微小RNA。我们发现结核分枝杆菌的sRNA_1096和sRNA_1414与人类mir-21具有序列同源性。因此，暗示了这三种小非编码RNA在肺结核利福平耐药性中的潜在作用。此外，推断出结核分枝杆菌的sRNA_1096和sRNA_1414与宿主肺肿瘤发生之间的联系。尽管如此，需要进一步的分析和验证来将这三种非编码RNA与分枝杆菌相关的肺癌风险增加联系起来。
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