Bremer J W, Neel H B, DeSanto L W, Jones G C
Laryngoscope. 1986 Dec;96(12):1321-9. doi: 10.1288/00005537-198612000-00001.
A series of 150 patients with histologically confirmed angiofibroma examined from 1945 through 1983 was studied to contrast treatment methods and surgical approaches. From 1945 to 1955, treatment consisted primarily of radiation. From 1955 through 1971, the primary method of treatment was surgical removal; the lateral rhinotomy approach was used to expose the tumor and its extensions in most cases. From 1971 through 1983, all tumors were removed surgically. Trends in diagnosis, treatment, and adjunctive therapy at a single institution were evaluated. Specifically, the trends considered were operative approaches, blood replacement with and without hypotensive anesthesia, adjunctive measures such as hormonal therapy or tumor embolization, mortality, and morbidity. Lateral rhinotomy provides wide exposure of and access to the nose, nasopharynx, paranasal sinuses, elements of the skull base, temporal fossa, and infratemporal fossa. Surgical treatment, specifically the lateral rhinotomy approach and its extensions, is recommended as the best method of managing angiofibroma in most patients.
对1945年至1983年间经组织学确诊的150例血管纤维瘤患者进行了研究，以对比治疗方法和手术入路。1945年至1955年，治疗主要采用放射治疗。1955年至1971年，主要治疗方法是手术切除；大多数情况下采用外侧鼻切开术入路来暴露肿瘤及其延伸部位。1971年至1983年，所有肿瘤均通过手术切除。评估了单一机构在诊断、治疗和辅助治疗方面的趋势。具体而言，所考虑的趋势包括手术入路、有无控制性低血压麻醉下的输血、激素治疗或肿瘤栓塞等辅助措施、死亡率和发病率。外侧鼻切开术可广泛暴露并进入鼻腔、鼻咽、鼻窦、颅底部分、颞窝和颞下窝。手术治疗，特别是外侧鼻切开术入路及其扩展术式，被推荐为大多数患者治疗血管纤维瘤的最佳方法。
