Morse Leslie R, Coker Jennifer, Battaglino Ricardo A
Rocky Mountain Regional Spinal Injury System, Craig Rehabilitation Hospital, Englewood, Colorado, United States of America.
Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Actual osteol. 2018 Jan-Apr;14(1):31-35.
Statins are a widely prescribed class of medications that inhibit similar pathways as the anti-resorptive bisphosphonate drugs. Statins target the mevalonate pathway by blocking HMG-CoA reductase. Several recent meta-analyses concluded statins are osteoprotective in the general population. Here we present current literature exploring the mechanisms underlying the putative osteoprotective effects of statins. We also review recent clinical studies, ranging from observational cohort studies to randomized clinical trials, testing the effect of statins on bone health in various populations.
他汀类药物是一类广泛应用的处方药，其作用途径与抗吸收双膦酸盐药物相似。他汀类药物通过阻断HMG-CoA还原酶来靶向甲羟戊酸途径。最近的几项荟萃分析得出结论，他汀类药物对普通人群具有骨保护作用。在此，我们展示了探索他汀类药物假定骨保护作用潜在机制的当前文献。我们还回顾了最近的临床研究，从观察性队列研究到随机临床试验，这些研究测试了他汀类药物对不同人群骨骼健康的影响。
