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硬皮病相关间质性肺炎的非吸烟者发生肺气肿

Emphysema formation in a never-smoker with scleroderma-related interstitial pneumonia.

作者信息

Yamakawa Hideaki, Takemura Tamiko, Baba Tomohisa, Ogura Takashi

机构信息

Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.

Department of Respiratory Medicine, Tokyo Jikei University Hospital, Tokyo, Japan.

出版信息

Respir Med Case Rep. 2018 Sep 13;25:211-212. doi: 10.1016/j.rmcr.2018.09.009. eCollection 2018.

DOI:10.1016/j.rmcr.2018.09.009
PMID:30237971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6143697/
Abstract

We report a case of pathological emphysema formation in a never-smoker with scleroderma-related interstitial pneumonia. We realized the importance of pulmonary vasculopathy causing the coexistence of emphysema and fibrosis in scleroderma. Our discovery provides novel information that emphysema can occur in patients with scleroderma-related interstitial pneumonia who have never smoked.

摘要

我们报告了一例患有硬皮病相关间质性肺炎的从不吸烟者发生病理性肺气肿的病例。我们认识到肺部血管病变在硬皮病中导致肺气肿和纤维化并存的重要性。我们的发现提供了新的信息,即肺气肿可发生在从未吸烟的硬皮病相关间质性肺炎患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/749d/6143697/3ef0b5b8be2f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/749d/6143697/3ef0b5b8be2f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/749d/6143697/3ef0b5b8be2f/gr1.jpg

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本文引用的文献

1
Emphysematous change with scleroderma-associated interstitial lung disease: the potential contribution of vasculopathy?硬皮病相关性间质性肺疾病合并气肿性改变:血管病变的潜在作用?
BMC Pulm Med. 2018 Jan 30;18(1):25. doi: 10.1186/s12890-018-0591-y.
2
Histological analysis of vasculopathy associated with pulmonary hypertension in combined pulmonary fibrosis and emphysema: comparison with idiopathic pulmonary fibrosis or emphysema alone.合并肺纤维化和肺气肿的肺动脉高压相关血管病变的组织学分析:与单纯特发性肺纤维化或肺气肿的比较
Histopathology. 2017 May;70(6):896-905. doi: 10.1111/his.13153. Epub 2017 Feb 8.
3
Combined Pulmonary Fibrosis and Emphysema in Scleroderma-Related Lung Disease Has a Major Confounding Effect on Lung Physiology and Screening for Pulmonary Hypertension.
硬皮病相关肺疾病中的合并性肺纤维化和肺气肿对肺生理学和肺动脉高压筛查有重大的混杂影响。
Arthritis Rheumatol. 2016 Apr;68(4):1004-12. doi: 10.1002/art.39528.
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Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study.轻度慢性阻塞性肺疾病和肺气肿中的肺微血管血流。MESA慢性阻塞性肺疾病研究。
Am J Respir Crit Care Med. 2015 Sep 1;192(5):570-80. doi: 10.1164/rccm.201411-2120OC.
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Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: a distinctive vasculopathy.局限性皮肤系统性硬化症中的肺动脉高压:一种独特的血管病变。
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Arterial and interstitial remodelling processes in non-specific interstitial pneumonia: systemic sclerosis versus idiopathic.非特异性间质性肺炎中的动脉和间质重塑过程:系统性硬化症与特发性之间的比较
Histopathology. 2008 Aug;53(2):195-204. doi: 10.1111/j.1365-2559.2008.03072.x.