Mustafa Amany I, El-Shimi Ola S
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
J Cosmet Dermatol. 2018 Oct;17(5):931-934. doi: 10.1111/jocd.12753. Epub 2018 Sep 20.
Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units. Adipokines are secreted by adipose tissue and function as signaling networks communicating it with different organs. They may have role in pathogenesis of acne vulgaris and the associated insulin resistance. Irisin, a hormone like myokine, is one of adipokines with anti-inflammatory, anti-oxidant, and anti-diabetic effects.
We aimed at evaluation of serum irisin level in patients with acne vulgaris to assess its correlation with disease pathogenesis.
Serum irisin level was measured by an ELISA technique in 60 acne vulgaris patients and 60 apparently healthy controls. Insulin resistance was calculated by Homeostasis Model Assessment of Insulin Resistance index.
Serum irisin level was significantly lower in acne vulgaris patients than control group (P < 0.001). It showed a significant negative correlation with insulin resistance among patients (P 0.012). Moreover, it was decreasing significantly with the increase in disease severity (P 0.004).
Our results revealed that lower serum irisin not only to be a biomarker of disease pathogenesis but also to be a potential prognostic predictor for severity in acne vulgaris.
寻常痤疮是一种常见的累及毛囊皮脂腺单位的慢性炎症性皮肤病。脂肪因子由脂肪组织分泌，作为与不同器官进行沟通的信号网络发挥作用。它们可能在寻常痤疮的发病机制及相关胰岛素抵抗中起作用。鸢尾素是一种类似肌动蛋白的激素，是具有抗炎、抗氧化和抗糖尿病作用的脂肪因子之一。
我们旨在评估寻常痤疮患者的血清鸢尾素水平，以评估其与疾病发病机制的相关性。
采用酶联免疫吸附测定（ELISA）技术检测60例寻常痤疮患者和60例明显健康对照者的血清鸢尾素水平。通过稳态模型评估胰岛素抵抗指数计算胰岛素抵抗。
寻常痤疮患者的血清鸢尾素水平显著低于对照组（P < 0.001）。在患者中，它与胰岛素抵抗呈显著负相关（P = 0.012）。此外，随着疾病严重程度的增加，它显著降低（P = 0.004）。
我们的结果显示，较低的血清鸢尾素不仅是疾病发病机制的生物标志物，也是寻常痤疮严重程度的潜在预后预测指标。
