医院居家治疗单位使用厄他培南的有效性和安全性：来自西班牙门诊肠外抗菌治疗登记处的数据。

Effectiveness and safety of ertapenem used in hospital-at-home units: data from Spanish Outpatient Parenteral Antimicrobial Therapy Registry.

机构信息

Hospital-at-Home unit, Valdecilla Hospital, Santander, Spain.

Teaching unit, Cantabria Health Care Service, Santander, Spain.

出版信息

Future Microbiol. 2018 Sep;13:1363-1373. doi: 10.2217/fmb-2018-0065. Epub 2018 Sep 21.

DOI:10.2217/fmb-2018-0065

PMID:30238769

Abstract

AIM

To evaluate the effectiveness and safety of ertapenem in patients hospitalized at home.

PATIENTS & METHODS: Retrospective analysis of data from Spanish Outpatient Parenteral Antimicrobial Therapy (OPAT) registry.

RESULTS

Data from 1428 patients (median age 70 years; 5.4% institutionalized) and 1547 infectious processes (24% self-administration) were analyzed. Clinical cure or improvement was achieved in 93.8% of cases. Rate of related readmissions was 4.2%, of clinically important complications -3.9%, and of adverse drug reactions -3.2%. High comorbidity burden, contagion in nursing home and certain types of infection were associated with worse prognosis. Self-administration was effective and safe, except in case of nursing home-acquired infections.

CONCLUSION

Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures.

摘要

目的

评估家庭住院患者使用厄他培南的疗效和安全性。

患者与方法

回顾性分析西班牙门诊肠外抗菌治疗（OPAT）登记处的数据。

结果

共分析了 1428 例患者（中位年龄 70 岁；5.4%为机构内患者）和 1547 例感染性疾病（24%为自行给药）。93.8%的患者临床治愈或好转。相关再入院率为 4.2%，临床重要并发症发生率为 3.9%，药物不良反应发生率为 3.2%。高合并症负担、疗养院感染和某些类型的感染与预后不良相关。除疗养院获得性感染外，自行给药是有效且安全的。