Department of Clinical Medicine, Aarhus University Hospital, Aarhus N, Denmark.
Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):475-480. doi: 10.1097/MCO.0000000000000513.
Isoflavones exert estrogenic activity distinct from estrogen, they have the potential to treat diseases and symptoms related to estrogen deficiency with minimal side effects and risks. Isoflavone supplementation, in general, is shown to exert beneficial effects against estrogen-deficient bone loss in women, however, some clinical trials still produce conflicting findings. The purpose of this review is to highlight and summarize the most recent and up-to-date research in the field and to bring attention to factors that play a major role in the outcomes of clinical trials that investigate phytoestrogens. Here, we also discuss the latest and most relevant data regarding the clinical safety of these substances.
Isoflavones are naturally occurring secondary metabolites found in the Fabacaea plant family. Clinical data from isoflavone interventions support that aglycones (abundant in fermented products) exert enhanced beneficial effects against estrogen-deficient bone loss in women compared with isoflavone glycosides. Studies that employ methods to determine isoflavone content and form of treatments are more likely detect beneficial effects on bone. EFSA have confirmed the safety of isoflavones for women in the most comprehensive report to date.
Isoflavone aglycones exert greater effects against bone loss than glycosides. Isoflavones show promise as a first-line prophylactic/treatment for bone loss in women.
异黄酮具有不同于雌激素的雌激素活性，它们有可能在最小的副作用和风险下治疗与雌激素缺乏相关的疾病和症状。异黄酮补充剂一般被证明对女性因雌激素缺乏导致的骨丢失有有益作用，但一些临床试验仍得出相互矛盾的结果。本综述的目的是强调和总结该领域最新的研究，并提请注意在研究植物雌激素的临床试验中起主要作用的因素。在这里，我们还讨论了这些物质临床安全性的最新和最相关的数据。
异黄酮是在豆科植物家族中发现的天然次生代谢物。异黄酮干预的临床数据支持，与异黄酮糖苷相比，苷元（在发酵产品中丰富）对女性因雌激素缺乏导致的骨丢失具有更强的有益作用。采用方法来确定治疗中异黄酮含量和形式的研究更有可能检测到对骨骼的有益作用。EFSA 在迄今为止最全面的报告中确认了异黄酮对女性的安全性。
异黄酮苷元对骨丢失的作用大于糖苷。异黄酮有望成为女性预防/治疗骨丢失的一线药物。
