Atmaca Aysegul, Kleerekoper Michael, Bayraktar Miyase, Kucuk Omer
Department of Internal Medicine, Ondokuz Mayis University, Samsun, Turkey.
Menopause. 2008 Jul-Aug;15(4 Pt 1):748-57. doi: 10.1097/gme.0b013e31815c1e7f.
This is a review article designed to address the effects of soy isoflavones on bone metabolism in postmenopausal women and their place in the prevention and treatment of postmenopausal osteoporosis. Soy isoflavones are natural products that could be used as an alternative to menopausal hormone therapy because they are structurally and functionally related to 17beta-estradiol. In vitro and animal studies have shown that they act in multiple ways to exert their bone-supporting effects. They act on both osteoblasts and osteoclasts through genomic and nongenomic pathways. Epidemiological studies and clinical trials suggest that soy isoflavones have beneficial effects on bone mineral density, bone turnover markers, and bone mechanical strength in postmenopausal women. However, there are conflicting results related to differences in study design, estrogen status of the body, metabolism of isoflavones among individuals, and other dietary factors. The long-term safety of soy isoflavone supplements remains to be demonstrated.
这是一篇综述文章，旨在探讨大豆异黄酮对绝经后女性骨代谢的影响及其在绝经后骨质疏松症预防和治疗中的地位。大豆异黄酮是天然产物，因其在结构和功能上与17β-雌二醇相关，故可作为绝经激素疗法的替代品。体外和动物研究表明，它们通过多种方式发挥其对骨骼的支持作用。它们通过基因组和非基因组途径作用于成骨细胞和破骨细胞。流行病学研究和临床试验表明，大豆异黄酮对绝经后女性的骨矿物质密度、骨转换标志物和骨力学强度具有有益作用。然而，由于研究设计、身体雌激素状态、个体间异黄酮代谢以及其他饮食因素的差异，结果存在矛盾。大豆异黄酮补充剂的长期安全性仍有待证实。
