Department of Neurosurgery.
Department of Nuclear Medicine, University Hospital Munich, Munich, Germany.
Curr Opin Neurol. 2018 Dec;31(6):720-726. doi: 10.1097/WCO.0000000000000616.
To give an overview on the current development in PET imaging as an additional tool in brain tumor management.
The rising emphasis on molecular tumor characteristics both in primary and in metastatic brain disease leads to an increased demand for noninvasive 'molecular' grading as well as treatment planning and surveillance of therapy effects. Metabolic imaging using amino acid PET provides further insights into tumor metabolism; current novelties comprise the use of hybrid PET/MRI scanners as well as development of new tracers. Furthermore, treatment monitoring and prognostication on the basis of amino acid PET is gaining further importance in neuro-oncological decision-making.
Due to its unique properties in visualization of tumor biology, amino acid PET will continue to gain further importance in primary and secondary brain tumors.
介绍 PET 成像在脑肿瘤管理中作为附加工具的最新发展。
原发性和转移性脑疾病中对分子肿瘤特征的重视日益增加，这导致对非侵入性“分子”分级以及治疗计划和治疗效果监测的需求增加。使用氨基酸 PET 进行代谢成像可进一步了解肿瘤代谢；目前的新进展包括使用混合 PET/MRI 扫描仪以及开发新的示踪剂。此外，基于氨基酸 PET 的治疗监测和预后在神经肿瘤学决策中变得越来越重要。
由于其在肿瘤生物学可视化方面的独特特性，氨基酸 PET 将继续在原发性和继发性脑肿瘤中得到进一步重视。
