细胞外囊泡在精神疾病研究中的应用。
Extracellular Vesicles for Research on Psychiatric Disorders.
机构信息
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD.
出版信息
Schizophr Bull. 2019 Jan 1;45(1):7-16. doi: 10.1093/schbul/sby127.
Abstract
Extracellular vesicles (EVs) have gained increasing attention as underexplored intercellular communication mechanisms in basic science and as potential diagnostic tools in translational studies, particularly those related to cancers and neurological disorders. This article summarizes accumulated findings in the basic biology of EVs, EV research methodology, and the roles of EVs in brain cell function and dysfunction, as well as emerging EV studies in human brain disorders. Further research on EVs in neurobiology and psychiatry may open the door to a better understanding of intercellular communications in healthy and diseased brains, and the discovery of novel biomarkers and new therapeutic strategies in psychiatric disorders.
摘要
细胞外囊泡 (EVs) 在基础科学中作为未充分探索的细胞间通讯机制，以及在转化研究中作为潜在的诊断工具，特别是在癌症和神经紊乱方面，引起了越来越多的关注。本文总结了细胞外囊泡的基础生物学、EV 研究方法学，以及 EV 在脑细胞功能和功能障碍中的作用，以及在人类脑部疾病中新兴的 EV 研究。进一步研究神经生物学和精神病学中的 EV 可能有助于更好地理解健康和患病大脑中的细胞间通讯，并发现精神疾病中的新型生物标志物和新的治疗策略。
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