Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang, China.
Brain Behav. 2018 Oct;8(10):e01115. doi: 10.1002/brb3.1115. Epub 2018 Sep 21.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is the most commonly observed phenotype among chronic acquired demyelinating polyneuropathies and is clinically variable. The aim of this meta-analysis was to evaluate the diagnostic value and characteristics of CIDP targeting neurofascin 155 (NF155).
A systematic literature search was performed on March 2018, and two reviewers independently extracted data and assessed the risk of bias on MEDLINE, EMBASE, the Web of Science, and the Cochrane Library to identify relevant articles.
Ten articles for the NF155 protein test with 1,161 patients and 1,636 controls were identified. The results showed that the pooled sensitivity was 0.09 (95% CI: 0.06-015), and specificity was 1.00 (95% CI: 0.98-1.00) of the NF155 for CIDP. The meta-analysis revealed that the sensory ataxic occurrence rate (OR: 10.79, 95% CI: 5.24-22.22) and tremor occurrence rate (OR: 6.71, 95% CI: 3.37-13.39) were higher among patients positive for NF155 compared with NF155-negative CIDP patients. However, the rate of good treatment response to intravenous immunoglobulin (IVIg) (OR: 0.09, 95% CI: 0.02-0.42) was lower in NF155-positive CIDP patients.
NF155 is a specific protein marker for CIDP, but its diagnostic value has been questioned due to low sensitivity. However, as an antibody against paranodal antigens, NF155 seems more valuable in defining clinical subsets of CIDP.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是慢性获得性脱髓鞘性多发性神经病中最常见的表型，临床表现多样。本荟萃分析的目的是评估针对神经束蛋白 155（NF155）的 CIDP 诊断价值和特征。
2018 年 3 月，我们进行了系统的文献检索，并由两名评审员独立提取数据，并评估 MEDLINE、EMBASE、Web of Science 和 Cochrane Library 上的偏倚风险，以识别相关文章。
共确定了 10 篇关于 NF155 蛋白检测的文章，纳入了 1161 名患者和 1636 名对照者。结果显示，NF155 对 CIDP 的合并敏感性为 0.09（95%CI：0.06-015），特异性为 1.00（95%CI：0.98-1.00）。荟萃分析显示，NF155 阳性患者的感觉运动性共济失调发生率（OR：10.79，95%CI：5.24-22.22）和震颤发生率（OR：6.71，95%CI：3.37-13.39）高于 NF155 阴性 CIDP 患者。然而，NF155 阳性 CIDP 患者对静脉注射免疫球蛋白（IVIg）的治疗反应良好率（OR：0.09，95%CI：0.02-0.42）较低。
NF155 是 CIDP 的特异性蛋白标志物，但由于敏感性较低，其诊断价值受到质疑。然而，作为针对神经节段抗原的抗体，NF155 在定义 CIDP 的临床亚型方面似乎更有价值。
