Beijing Agro-Biotechnology Research Center , Beijing Academy of Agriculture and Forestry Sciences , Beijing 100097 , China.
Department of Molecular Biosciences and Bioengineering , University of Hawaii at Manoa , Honolulu , Hawaii 96822 , United States.
J Agric Food Chem. 2018 Oct 10;66(40):10431-10437. doi: 10.1021/acs.jafc.8b03865. Epub 2018 Oct 2.
Flavonoids are characteristic in maize and have diverse biological functions. C-Glycosylflavones are neuroprotective against β-amyloid-induced tau hyperphosphorylation and neurotoxicity in SH-SY5Y cells, which is relevant to Alzheimer's disease prevention and treatment. The content of the flavonoids eriodictyol, luteolin, isoorientin, and maysin varied in pollens, silks, tassels, and seeds among five maize varieties. Eriodictyol content was high (51-322 ng/g dw) in pollens, while luteolin content was low (0.2-106 ng/g dw) in all four tissues. The isoorientin content was approximately 3- to 10-fold greater than eriodictyol in pollens and tassels, particularly in the hybrid M1 and sweet corn M5 varieties. Maysin content was high in most silks and tassels. The differential expression of five genes involved in the maysin biosynthesis correlated well with the profiles of the four flavonoids among tissues and varieties. The present study offers valuable data for maize breeding and the use of maize flavonoids as functional food components.
类黄酮是玉米的特征成分，具有多种生物学功能。C-糖苷黄酮可预防β-淀粉样蛋白诱导的 SH-SY5Y 细胞中 tau 的过度磷酸化和神经毒性，与阿尔茨海默病的预防和治疗有关。在五种玉米品种的花粉、花丝、穗和种子中，类黄酮柚皮苷、木樨草素、异荭草素和玉米黄质的含量有所不同。花粉中柚皮苷含量较高（51-322ng/g dw），而所有四种组织中木樨草素含量较低（0.2-106ng/g dw）。在花粉和穗中，异荭草素的含量约为柚皮苷的 3-10 倍，特别是在杂交种 M1 和甜玉米 M5 品种中。大多数花丝和穗中玉米黄质含量较高。与组织和品种中四种类黄酮的特征一致，参与玉米黄质生物合成的五个基因的差异表达与五种基因的表达谱密切相关。本研究为玉米的选育和利用玉米类黄酮作为功能性食品成分提供了有价值的数据。
