Department of Genetics, Washington University School of Medicine , Saint Louis, Missouri.
Physiol Genomics. 2018 Nov 1;50(11):947-955. doi: 10.1152/physiolgenomics.00072.2018. Epub 2018 Sep 21.
The dramatic increase in global prevalence of metabolic disease is inexplicable when considering only environmental or only genetic factors, leading to the need to explore the possible roles of epigenetic factors. A great deal of progress has been made in this interdisciplinary field in recent years, with many studies investigating various aspects of the metabolic syndrome and its associated epigenetic changes. Rodent models of metabolic diseases have been particularly illuminating because of the ability to leverage tools such as genetic and environmental modifications. The current review summarizes recent breakthroughs regarding epigenetic markers in studies of obesity, Type II diabetes, and cardiovascular disease, the three major disorders associated with metabolic syndrome. We also discuss open questions and future directions for integrating genomic, epigenomic, and phenotypic big biodata toward understanding metabolic syndrome etiology.
当仅考虑环境或遗传因素时，全球代谢性疾病患病率的急剧上升是无法解释的，这促使人们需要探索表观遗传因素的可能作用。近年来，这个跨学科领域取得了很大的进展，许多研究调查了代谢综合征及其相关表观遗传变化的各个方面。代谢性疾病的啮齿动物模型特别有启发性，因为能够利用遗传和环境修饰等工具。本综述总结了肥胖症、2 型糖尿病和心血管疾病（与代谢综合征相关的三大疾病）研究中有关表观遗传标记物的最新突破。我们还讨论了整合基因组、表观基因组和表型大生物数据以了解代谢综合征病因的一些开放性问题和未来方向。
