Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Ministry of Education Key Laboratory of Molecular Microbiology and Technology, Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China.
Fungal Genet Biol. 2018 Nov;120:42-52. doi: 10.1016/j.fgb.2018.09.006. Epub 2018 Sep 18.
Mitochondria are dynamic organelles, and their shapes and sizes are regulated by mitochondrial fusion and fission. The proteins essential for mitochondrial fusion in Candida albicans have not been clearly characterized. In this study, Mgm1 was explored for its roles in mitochondrial function, cell cycle, hyphal growth and virulence in this pathogen. The deletion of MGM1 led to mitochondrial fragmentation and mtDNA loss and activated the checkpoint pathway to arrest the cell cycle in G1 phase. Moreover, loss of MGM1 led to defects in hyphal development and attenuation of virulence in a macrophage cell line and a mouse model of disseminated infection. These results reveal that Mgm1 plays an important role in mitochondrial dynamics and function, cell cycle progression, hyphal development and virulence in C. albicans.
线粒体是动态细胞器，其形状和大小受线粒体融合和裂变的调节。白色念珠菌中线粒体融合所必需的蛋白质尚未得到明确表征。在这项研究中，Mgm1 被探索用于其在该病原体中线粒体功能、细胞周期、菌丝生长和毒力中的作用。MGM1 的缺失导致线粒体碎片化和 mtDNA 丢失，并激活检查点途径使细胞周期在 G1 期停滞。此外，MGM1 的缺失导致菌丝发育缺陷和毒力减弱，在巨噬细胞系和播散性感染的小鼠模型中。这些结果表明，Mgm1 在白色念珠菌中线粒体动力学和功能、细胞周期进程、菌丝发育和毒力中发挥重要作用。
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