Ni Yue, Gao Xindi
College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China.
Department of Emergency, Xinqiao Hospital, Army Medical University, Chongqing, China.
Front Cell Infect Microbiol. 2025 Apr 16;15:1576485. doi: 10.3389/fcimb.2025.1576485. eCollection 2025.
Fungal infections are becoming more prevalent globally, particularly affecting immunocompromised populations, such as people living with HIV, organ transplant recipients and those on immunomodulatory therapy. Globally, approximately 6.55 million people are affected by invasive fungal infections annually, leading to serious health consequences and death. Mitochondria are membrane-bound organelles found in almost all eukaryotic cells and play an important role in cellular metabolism and energy production, including pathogenic fungi. These organelles possess their own genome, the mitochondrial genome, which is usually circular and encodes proteins essential for energy production. Variation and evolutionary adaptation within and between species' mitochondrial genomes can affect mitochondrial function, and consequently cellular energy production and metabolic activity, which may contribute to pathogenicity and drug resistance in certain fungal species. This review explores the link between the mitochondrial genome and mechanisms of fungal pathogenicity and drug resistance, with a particular focus on and . These insights deepen our understanding of fungal biology and may provide new avenues for developing innovative therapeutic strategies.
真菌感染在全球范围内正变得越来越普遍，尤其影响免疫功能低下人群，如艾滋病毒感染者、器官移植受者以及接受免疫调节治疗的患者。在全球范围内，每年约有655万人受到侵袭性真菌感染的影响，导致严重的健康后果甚至死亡。线粒体是几乎所有真核细胞中存在的膜结合细胞器，在细胞代谢和能量产生中发挥重要作用，包括致病真菌。这些细胞器拥有自己的基因组，即线粒体基因组，通常是环状的，编码能量产生所必需的蛋白质。物种线粒体内和线粒体间的变异及进化适应会影响线粒体功能，进而影响细胞能量产生和代谢活动，这可能导致某些真菌物种的致病性和耐药性。本综述探讨了线粒体基因组与真菌致病性和耐药机制之间的联系，尤其关注[此处原文缺失具体内容]和[此处原文缺失具体内容]。这些见解加深了我们对真菌生物学的理解，并可能为开发创新治疗策略提供新途径。
