Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA, 23507, United States.
Department of Dermatology, Massachusetts General Hospital, 50 Staniford Street, Suite 200, Boston, MA, 02114, United States.
Photodiagnosis Photodyn Ther. 2018 Dec;24:109-114. doi: 10.1016/j.pdpdt.2018.09.009. Epub 2018 Sep 18.
The aim of this review is to provide clinicians with an overview of outcomes in the current literature concerning the use of Photodynamic Therapy to treat Bowen's Disease, also known as Squamous Cell Carcinoma in situ. The review discusses clinical response, recurrence rates, cosmetic outcomes, and adverse effects. Strong evidence shows that PDT is an effective therapy for SCCis with acceptable clinical response rates and lower recurrence rates in comparison to conventional therapies such as cryotherapy and 5-fluorouracil. Furthermore, PDT is associated with superior cosmetic outcomes and is generally well tolerated by patients, with minimal side effects. PDT is especially useful in patients with multiple lesions and those whom are considered to be non-surgical candidates.
本次综述的目的是为临床医生提供目前有关光动力疗法治疗 Bowen 病（也称为原位鳞状细胞癌）的文献结果概述。综述讨论了临床反应、复发率、美容效果和不良反应。有强有力的证据表明，与冷冻疗法和 5-氟尿嘧啶等传统疗法相比，PDT 是 SCCis 的一种有效治疗方法，具有可接受的临床反应率和较低的复发率。此外，PDT 与较好的美容效果相关，并且通常被患者很好地耐受，副作用很小。PDT 特别适用于多发性病变和不适合手术的患者。
