Park Hae-Eun, Park Jin-Woo, Kim Yeong-Ho, Han Ju-Hee, Bang Chul-Hwan, Park Young-Min, Lee Ji-Hyun
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
J Clin Med. 2022 May 12;11(10):2741. doi: 10.3390/jcm11102741.
Treatment options for Bowen's disease (BD) include surgical excision, cryotherapy, curettage with cautery, topical 5-fluorouracil or imiquimod, and photodynamic therapy. However, it is not clear which treatment is the most effective due to lack of studies. We reviewed the electronic medical records of 158 patients who were diagnosed with BD and treated at Seoul St. Mary's Hospital from January 2011 to December 2020. Treatment modalities were surgical excision, cryotherapy, photodynamic therapy, and imiquimod. A total of 121 patients was enrolled in this study. The average treatment period was longest for cryotherapy, followed by imiquimod, PDT, and excision (119.53, 87.75, 68.50, and 1 day, respectively). The therapeutic efficacy was highest in the surgical excision group (100%) and lowest in the PDT group (62.5%). The recurrence rate was highest in the imiquimod group (33.33%). Surprisingly, only in patients treated with cryotherapy, satellite lesions developed in 9.09% of them during follow-up. Surgical excision exhibited the highest clearance rate and the lowest recurrence rate, and its treatment period was the shortest, confirming that it remains the gold standard. In contrast, since cryotherapy demonstrated a relatively high recurrence rate including development of satellite lesions, careful monitoring is required when performing cryotherapy for treatment of BD.
鲍恩病（BD）的治疗选择包括手术切除、冷冻疗法、刮除术加烧灼、外用5-氟尿嘧啶或咪喹莫特以及光动力疗法。然而，由于缺乏研究，尚不清楚哪种治疗方法最有效。我们回顾了2011年1月至2020年12月在首尔圣玛丽医院被诊断为BD并接受治疗的158例患者的电子病历。治疗方式包括手术切除、冷冻疗法、光动力疗法和咪喹莫特。本研究共纳入121例患者。冷冻疗法的平均治疗周期最长，其次是咪喹莫特、光动力疗法和手术切除（分别为119.53天、87.75天、68.50天和1天）。手术切除组的治疗效果最高（100%），光动力疗法组最低（62.5%）。咪喹莫特组的复发率最高（33.33%）。令人惊讶的是，仅在接受冷冻疗法的患者中，9.09%的患者在随访期间出现了卫星病灶。手术切除显示出最高的清除率和最低的复发率，且其治疗周期最短，证实其仍是金标准。相比之下，由于冷冻疗法显示出相对较高的复发率，包括卫星病灶的出现，因此在对BD进行冷冻治疗时需要仔细监测。
