National Institute of Mental Health, Klecany, Czech Republic; Department of Psychiatry and Psychotherapy, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Human Science Centre, Institute of Medical Psychology, Ludwig-Maximilian University, Munich, Germany.
Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Science, Moscow, Russian Federation.
Clin Neurophysiol. 2018 Nov;129(11):2315-2324. doi: 10.1016/j.clinph.2018.08.020. Epub 2018 Sep 6.
To evaluate the coherence values of the cortical bands in patients with first episode schizophrenia and schizoaffective disorder during the performance of a mental arithmetic task.
We analysed EEG coherence in the resting state and subsequently while counting down from 200 in steps of 7 in 32 first episode schizophrenia patients (SZ), 32 patients with first episode schizoaffective disorder (SA) and 40 healthy controls (HC).
Task performance in HC is characterised by decreased coherence in the alpha bands and increased coherence in the beta 2 and gamma bands in frontal sites. In SZ, coherence decreases in the alpha band, whereas in SA it substantially increases in the alpha, beta1, beta 2 and gamma bands.
Despite no differences in performance on a behavioural level, SA patients demonstrate a paradoxical increase in both low and fast frequency bands during the performance of a mental arithmetic task, while, patients with SZ show a decreased coherence in the alpha band, presumably alluding to the excessive excitatory (in SA) and inhibitory (in SZ) mechanisms in cognitive processing.
The current study provides evidence for the distinction of neurophysiological mechanisms of cognitive processing between SZ and SA.
评估首发精神分裂症和分裂情感障碍患者在进行心算任务时皮质带的相干值。
我们分析了 32 例首发精神分裂症患者（SZ）、32 例首发分裂情感障碍患者（SA）和 40 名健康对照者（HC）在静息状态和随后从 200 倒数到 7 的步骤中进行心算任务时的 EEG 相干性。
HC 的任务表现特征是额区的α频段相干性降低，β2 和γ频段的相干性增加。在 SZ 中，α 频段的相干性降低，而在 SA 中，α、β1、β2 和γ 频段的相干性显著增加。
尽管在行为水平上没有差异，但 SA 患者在进行心算任务时，低频和快频带均表现出反常增加，而 SZ 患者的α 频段相干性降低，这可能暗示认知处理中过度兴奋（在 SA 中）和抑制（在 SZ 中）机制。
本研究为区分 SZ 和 SA 的认知加工神经生理机制提供了证据。
