圈养美国牛蛙（牛蛙属）感染牛分枝杆菌引起的结核病
Tuberculosis caused by Mycobacterium bovis infection in a captive-bred American bullfrog (Lithobates catesbeiana).
作者信息
Ikuta Cassia Yumi, Reisfeld Laura, Silvatti Bruna, Salvagni Fernanda Auciello, de Paula Catia Dejuste, Pessier Allan Patrick, Catão-Dias José Luiz, Ferreira Neto José Soares
机构信息
Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Avenida Prof. Dr. Orlando marques de Paiva 87, São Paulo, SP, 05508-270, Brazil.
Aquário de São Paulo, Rua Huet Bacelar 407, São Paulo, SP, 04275-000, Brazil.
出版信息
BMC Vet Res. 2018 Sep 21;14(1):289. doi: 10.1186/s12917-018-1618-6.
BACKGROUND
Tuberculosis is widely known as a progressive disease that affects endothermic animals, leading to death and/or economical losses, while mycobacterial infections in amphibians are commonly due to nontuberculous mycobacteria. To the authors' knowledge, this report describes the first case of bovine tuberculosis in a poikilothermic animal.
CASE PRESENTATION
An adult female captive American bullfrog (Lithobates catesbeianus Shaw, 1802) died in a Brazilian aquarium. Multiple granulomas with acid-fast bacilli were observed in several organs. Identification of Mycobacterium bovis was accomplished by culture and PCR methods. The other animals from the same enclosure were euthanized, but no evidence of mycobacterial infection was observed.
CONCLUSIONS
The American bullfrog was introduced in several countries around the world as an alternative husbandry, and its production is purposed for zoological and aquarium collections, biomedical research, education, human consumption and pet market. The present report warns about an episode of bovine tuberculosis in an amphibian, therefore further studies are necessary to define this frog species' role in the epidemiology of M. bovis.
背景
结核病是一种广为人知的渐进性疾病，会影响恒温动物，导致死亡和/或经济损失，而两栖动物的分枝杆菌感染通常由非结核分枝杆菌引起。据作者所知，本报告描述了首例变温动物感染牛结核病的病例。
病例介绍
一只成年雌性圈养美国牛蛙（牛蛙，1802年肖氏命名）在巴西一家水族馆死亡。在多个器官中观察到多个含有抗酸杆菌的肉芽肿。通过培养和PCR方法鉴定出牛分枝杆菌。同一围栏中的其他动物被安乐死，但未观察到分枝杆菌感染的迹象。
结论
美国牛蛙作为一种替代养殖品种被引入世界多个国家，其养殖目的是用于动物园和水族馆收藏、生物医学研究、教育、人类消费和宠物市场。本报告警示了两栖动物感染牛结核病的一个案例，因此有必要进一步研究以确定这种蛙类在牛分枝杆菌流行病学中的作用。
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