VIB Center for Inflammation Research, Ghent University, Ghent, Belgium.
Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium.
Nat Rev Immunol. 2018 Dec;18(12):745-758. doi: 10.1038/s41577-018-0068-5.
Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells - for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors - are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17.
蛋白水解作用是一种不可逆的生理过程，可导致蛋白质功能的终止或激活。许多参与免疫细胞和结构细胞之间细胞通讯的跨膜蛋白，例如 Notch、CD23、CD44 和膜锚定细胞因子及其受体，都被 ADAM（解整合素和金属蛋白酶）家族的酶切割。在这里，我们综述了 ADAM 蛋白在免疫系统发育和调节中的分子激活、底物特异性和功能的最新见解，特别关注了 ADAM10 和 ADAM17 的作用。
