ADAM10 的出现作为淋巴细胞发育和自身免疫的调节剂。
The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity.
机构信息
Department of Microbiology and Immunology, Virginia Commonwealth University, School of Medicine, P.O. Box 980678, Richmond, VA 23298, USA.
出版信息
Mol Immunol. 2011 Jun;48(11):1319-27. doi: 10.1016/j.molimm.2010.12.005. Epub 2011 Jan 13.
Abstract
Proteolytic processing of transmembrane receptors and ligands can have a dramatic impact on cell signaling processes and subsequent cellular responses, including activation and differentiation. A member of the disintegrin and metalloproteinase family, ADAM10, has emerged as a prominent regulator of numerous receptors and ligands, including Notch and CD23. Here, we review studies resulting from the recent generation of ADAM10 conditional knockout mice which revealed a critical role for ADAM10 in Notch-dependent lymphocyte development. Additionally, we discuss results of numerous in vitro and ex vivo studies indicating that ADAM10 regulates the production of multiple secreted factors that contribute to autoimmune reactions.
摘要
蛋白水解处理跨膜受体和配体对细胞信号转导过程和随后的细胞反应有显著影响，包括激活和分化。解整合素和金属蛋白酶家族的一个成员 ADAM10 已成为众多受体和配体（包括 Notch 和 CD23）的重要调节剂。在这里，我们回顾了最近生成的 ADAM10 条件性敲除小鼠的研究结果，这些结果揭示了 ADAM10 在 Notch 依赖性淋巴细胞发育中的关键作用。此外，我们还讨论了许多体外和体内研究的结果，这些结果表明 ADAM10 调节多种分泌因子的产生，这些因子有助于自身免疫反应。
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