Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Applied Statistics, Yonsei University, Seoul, Republic of Korea.
Sci Rep. 2018 Sep 21;8(1):14182. doi: 10.1038/s41598-018-32499-8.
The degree of visual field (VF) loss can vary widely at a given level of retinal nerve fiber layer (RNFL) thickness. The cause of this variability is not fully understood. This cross-sectional study investigated whether the presence of choroidal microvasculature dropout (MvD) influences on the structure-function relationship among glaucomatous eyes. Seventy-one primary open-angle glaucoma (POAG) patients with choroidal MvD as determined by optical coherence tomography angiography (MvD+ group), and 71 age- and inferotemporal (IT) RNFL thickness-matched POAG patients without MvD (MvD- group) were included. VF sensitivity within the region corresponding to the IT RNFL sector was averaged using the total and pattern deviation fields. The slope of log-scale RNFL thickness versus VF defect was significantly steeper for the MvD+ than the MvD- group, as determined by both total and pattern deviation maps (P = 0.004 and <0.001, respectively). Both total and pattern VF deviation were significantly worse in the MvD+ than in the MvD- group (P = 0.002 and 0.007, respectively). Same results were obtained in subgroup analyses for eyes with thick and thin RNFL thickness (all P ≤ 0.027). These data suggest that parapapillary MvD is associated with poorer function of the remaining axons in eyes with POAG.
在给定的视网膜神经纤维层 (RNFL) 厚度水平下，视野 (VF) 损失的程度可能差异很大。这种可变性的原因尚未完全了解。本横断面研究调查了脉络膜微脉管系统缺失 (MvD) 是否会影响青光眼眼之间的结构-功能关系。通过光相干断层扫描血管造影 (MvD+ 组) 确定存在脉络膜 MvD 的 71 例原发性开角型青光眼 (POAG) 患者和 71 例年龄和下方 RNFL 厚度匹配的无 MvD 的 POAG 患者 (MvD- 组)。使用总偏差和模式偏差字段平均对应于下方 RNFL 扇区的 VF 灵敏度。MvD+ 组的 log 尺度 RNFL 厚度与 VF 缺陷的斜率明显比 MvD- 组陡峭，无论是总偏差还是模式偏差图都表明了这一点（P = 0.004 和 <0.001，分别）。与 MvD- 组相比，MvD+ 组的总偏差和模式偏差都明显更差（P = 0.002 和 0.007，分别）。在下方 RNFL 厚度较厚和较薄的眼睛的亚组分析中也得到了相同的结果（所有 P ≤ 0.027）。这些数据表明，旁视盘 MvD 与 POAG 眼剩余轴突的功能较差有关。
